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22579

RENO-PROTECTIVE EFFICACY OF AQUEOUS <i>CINNAMON BURMANNI</i> EXTRACT ON MULTI-WALLED CARBON NANOTUBES-INDUCED TOXICITY

Article

Last updated: 03 Jan 2025

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Tags

Animal Histology
Animal Physiology

Abstract

Multi-walled carbon nanotubes (MWCNTs) are widely used in industrial and biomedical applications. Exposure to these tubes causes inflammation, oxidative stress and/or function disorders in the body tissues and systems. The use of certain natural products that have antioxidant and/or anti-inflammatory activities might decrease this toxicity. Thus, the present study aims to assess the four weeks toxicity effect of inhaled MWCNTS on the kidneys of male rats, and the possible protective effect of aqueous extract of Cinnamon Burmanni (C. Burmanni). MWCNTs were synthesized in nano-photonic lab (Faculty of Science, Beni-Suef University). Thirty-two male rats (Rattus norvegicus) were divided equally into 4 groups: control group, cinnamon-treated group (daily, orally administrated 75 mg/kg body weight of aqueous C. Burmanni extract for 4 consecutive weeks), MWCNTs-treated group (animals were subjected to wood shaving cage litter containing 1.0 g MWCNTs/kg body weight, twice a week), and cinnamon and MWCNTs-treated group (treated simultaneously with both MWCNTs and aqueous C. Burmanni extract). Estimation of nitrite content, total thiols and reduced glutathione (GSH) concentrations, as well as glutathione S-transferase (GST) and glutathione peroxidase (GPx) activities in serum, in addition to the histopathological examination of kidney sections, were carried out. MWCNTs exposure resulted in significant elevation of nitrite content with significant decrease in GSH and total thiols levels and GST activity, and non-significant change in GPx activity in the serum samples. Histopathological studies of MWCNTs inhaled rats showed proteinaceous material accumulation in the lumen of renal tubules, vacuolation and congestion of glomerular tufts and perivascular oedema. Aqueous C. Burmanni extract greatly ameliorated these lesions via a significant decrease in serum nitrite content and significant elevation of serum GSH and total thiols contents as well as GST and GPx activity compared to their respective controls. In conclusion, aqueous C. Burmanni extract showed reno-protective effect against MWCNTs-induced cytoxicity via lowering reactive nitrogen species level and alleviating antioxidant enzymatic and non-enzymatic markers.

DOI

10.12816/0043188

Keywords

<i>Cinnamon burmanni</i>, histopathology, kidney, carbon nanotubes, Oxidative Stress, toxicity

Authors

First Name

Khaled

Last Name

Abdou

MiddleName

Abbas Helmy

Affiliation

Forensic Medicine and Toxicology Department, Faculty of Veterinary Medicine, Beni-Suef University, Beni-Suef, Egypt

Email

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City

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Orcid

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First Name

Rasha

Last Name

Ahmed

MiddleName

Rashad

Affiliation

Zoology Department, Faculty of Science, Beni-Suef University, Beni-Suef, Egypt

Email

-

City

-

Orcid

-

First Name

Marwa

Last Name

Ibrahim

MiddleName

A.

Affiliation

Biochemistry Department, Faculty of Veterinary Medicine, Cairo University, Giza, Egypt

Email

-

City

-

Orcid

-

First Name

Doaa

Last Name

Abdel-Gawad

MiddleName

Ramadan Ismail

Affiliation

Forensic Medicine and Toxicology Department, Faculty of Veterinary Medicine, Beni-Suef University, Beni-Suef, Egypt

Email

-

City

-

Orcid

-

Volume

68

Article Issue

68

Related Issue

4280

Issue Date

2017-12-01

Receive Date

2017-12-01

Publish Date

2017-12-01

Page Start

197

Page End

220

Print ISSN

1110-6344

Online ISSN

2682-3160

Link

https://ejz.journals.ekb.eg/article_22579.html

Detail API

https://ejz.journals.ekb.eg/service?article_code=22579

Order

11

Type

Original Research Papers

Type Code

684

Publication Type

Journal

Publication Title

Egyptian Journal of Zoology

Publication Link

https://ejz.journals.ekb.eg/

MainTitle

RENO-PROTECTIVE EFFICACY OF AQUEOUS <i>CINNAMON BURMANNI</i> EXTRACT ON MULTI-WALLED CARBON NANOTUBES-INDUCED TOXICITY

Details

Type

Article

Created At

22 Jan 2023