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23075

EVALUATING THE EFFICACY OF THE METHANOLIC EXTRACT OF HOPBUSH, <i>DODONAEA VISCOSA</i> (L.) JACQ, AS AN ANTI-FERTILITY AGENT: A PRELUDE TO ITS USE IN THE CONTROL OF THE HOUSE MOUSE

Article

Last updated: 03 Jan 2025

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Subjects

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Tags

Animal Ecology and Toxicology
Animal Histology

Abstract

The present work deals with evaluating the anti-fertility effects of the methanolic extract of hopbush, D. viscosa as a prelude to using it in the control of commensal house mice. In exploratory tests, the plant extract was given orally to male albino mice at concentrations of 200 and 400 mg/kg for 21 days. In case of females, the extract was given orally at a concentration 400 mg/kg for 17 days. The results indicated that this extract had significantly decreased the sperm count, and caused severe histopathological changes in the testes of treated males. On the other hand, it did not have any contragestive effects on treated females. The extract was then presented to male commensal mice in the form of a bait formulation, which proved to be acceptable by these males. They consumed a daily amount of 500 mg/kg for 21 days. This amount of the plant extract had caused a reduction in sperm number, degeneration in most seminferous tubules with the appearance of numerous cytoplasmic vacuoles, and nuclear pyknosis in most spermatogenic cells. It is recommended that D. viscosa extract be used in the control of the house mouse in the frame of integrated pest management programs.

DOI

10.12816/0037847

Keywords

Anti-fertility, <i>Dodonaea viscosa</i>, <i>Mus musculus</i>

Authors

First Name

Sohail

Last Name

Soliman

MiddleName

-

Affiliation

Department of Zoology, Faculty of Science, Ain Shams University, Cario, Egypt

Email

-

City

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Orcid

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First Name

Hamza

Last Name

EL-Shabaka

MiddleName

Ahmed

Affiliation

Department of Zoology, Faculty of Science, Ain Shams University, Cario, Egypt

Email

-

City

-

Orcid

-

First Name

Sameeh

Last Name

Mansour

MiddleName

A.

Affiliation

Environmental Toxicology Research Unit, National Research Centre, Giza, Egypt

Email

-

City

-

Orcid

-

First Name

Maha

Last Name

Hussein

MiddleName

Mostafa

Affiliation

Department of Zoology, Faculty of Science, Ain Shams University, Cario, Egypt

Email

-

City

-

Orcid

-

Volume

67

Article Issue

67

Related Issue

4334

Issue Date

2017-06-01

Receive Date

2017-06-01

Publish Date

2017-06-01

Page Start

281

Page End

294

Print ISSN

1110-6344

Online ISSN

2682-3160

Link

https://ejz.journals.ekb.eg/article_23075.html

Detail API

https://ejz.journals.ekb.eg/service?article_code=23075

Order

16

Type

Original Research Papers

Type Code

684

Publication Type

Journal

Publication Title

Egyptian Journal of Zoology

Publication Link

https://ejz.journals.ekb.eg/

MainTitle

EVALUATING THE EFFICACY OF THE METHANOLIC EXTRACT OF HOPBUSH, <i>DODONAEA VISCOSA</i> (L.) JACQ, AS AN ANTI-FERTILITY AGENT: A PRELUDE TO ITS USE IN THE CONTROL OF THE HOUSE MOUSE, <i>MUS MUSCULUS</i> LINNAEUS, 1758, IN EGYPT

Details

Type

Article

Created At

22 Jan 2023