The aim of this study was to compare morphometric measurements of different populations of Mesostena angustata in Egypt. A multivariate comparison of morphometric differences was undertaken by eyepiece micrometer on 8 different ecogeographical areas from Egypt fall under Western Desert, El Faiyum Depression, Eastern Desert and South Sinai. Twenty-one morphometric measurements were taken. Traits best corresponding to the distinction of populations were distinguished by cluster analysis and the principal component analysis. The first and second principle component axes (PC1 and PC2) recorded 34.29% and 14.36%, respectively, of the total variation in samples. Multiple discriminant analysis revealed clear morphometric differences between Western Desert, El Faiyum Depression, Eastern Desert and South Sinai populations. Traits explaining most of variability between populations were those connected with morphological measurements.