Background: Leiomyomatosis peritonealis disseminata (LPD) is very occasional disorder noted by formation of numerous nodules which spread across the peritoneal and omental surfaces. It is a benign ¹³ disease of unknown etiology and usually occurs in women of childbearing age.
Cases: This case report study included two cases. The first one is a 29 years-old female hospitalized for an elective cesarean section. A large omental mass and multiple small nodules in the ovary and intestine were observed incidentally after fetal delivery and expulsion of the uterus that was initially considered as leiomyosarcoma. The histopathology and immune-histochemistry of the masses were consistent with the diagnosis of DPL. The second one is a case of 30 weeks pregnant women presented with acute abdominal pain. Her age was 31-years-old. She was hospitalized for diagnosis and management. Investigations showed elevated inflammatory serum markers. An exploratory laparotomy was performed at 30 weeks of gestation to confirmed presence of tumers. All visible tumors were removed. In the subsequent pregnancy evidence of recurrent LPD lesions with no symptoms will be expected in such cases. 
Objective: The main objective of this case report is to clarify the role of immunohistochemistry in the diagnosis of LPD and to differentiate it from other mimicmalignant peritoneal tumors. Also, to simplify the clinical data regarding delivery and follow-up information for patients with LPD that developed during pregnancy.