ABSTRACT Background: Infertility in most cultures across the world is considered as a stain and shame which leads to the infertile women suffering. It also affects all features of their quality of life (QOL). Measuring the QOL is a benchmark in today's world of medicine. Objective: to determine emotional aspect of QOL and related factors among Egyptian infertile females attending IICPSR, Al-Azhar University. Methodology: this is an analytical cross-sectional study, conducted on 320 infertile women attending the International Islamic Center for population Studies and Research (IICPSR)- Al-Azhar University. Data were collected via the QOL Questionnaire of Infertile females. Socio-demographic data also were inquired and the collected data was analyzed using descriptive and analytical statistics (SPSS 19 program). Results: data analysis revealed that the mean age of the participants was 28.99 ± 3.9, mean duration of marriage was 4.7 ± 2.7, of all the studied women 167 (52.2%) were employed, 245 (76.55%) obese or overweight, and 194 (60.6%) were living in rural area. Positive, neutral, and negative scores of QOL of infertile females were discovered among (44.1%), (43.1%), (12.8%) individuals respectively. Conclusion: Infertility has a major effect on the emotional status of the infertile women. Age of infertile females, body mass index, frequency of treatment and level of education, are found to be the most important factors affecting the QOL.