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146337

Left Ventricular Geometry and N-terminal Pro-Brain Natriuretic Peptide in Egyptian Children with Chronic Kidney Disease.

Article

Last updated: 22 Jan 2023

Subjects

-

Tags

Chronic Kidney Disease

Abstract

Introduction: Cardiovascular disease is the main cause of death in Chronic Kidney disease (CKD) patients especially for those on dialysis. Left ventricular echocardiography changes are common. N-terminal pro-Brain Natriuretic peptide (NAP) is a sensitive predictor for ventricular stress.  
Aim of the Study: Our aim is to assess left ventricular Echocardiography abnormalities in CKD patients and their relation to serum NT pro BNP levels.
Methods: TheStudy included; 51 patients with different stages of CKD (21 patients were (CKD1-4) on predialysis conservative treatment, 30 patients with (CKD 5) on hemodialysis), and 20 healthy control group. Patients were subjected to echocardiography and serum measurement of BNP by enzyme linked immunosorbent assay.
Results: Abnormal left ventricular geometry patterns were seen in 17/21 (81%) CKD pre dialysis patients (concentric hypertrophy in 8 patients, eccentric hypertrophy in 8 patients and concentric remodeling in one patient). Those on dialysis 28/30 (93%) showed abnormal left ventricular geometry patterns (23 had concentric hypertrophy, 4 had eccentric hypertrophy and one patient had concentric remodeling). Mean NT pro BNP level was significantly higher in ESRD on dialysis (182.49 ± 136.57) vs pre dialysis group (29.72 ± 34.77) and control group (1.13 ± 2.97) (p < 0.001). Total patient sample (51cases) showed significant positive correlations between NT pro BNP level with hypertension, left ventricular mass (LVM), LVM2.7, LVM2, relative wall thickness (RWT) and serum creatinine (p = 0.0007, 0.01, 0.0007, 0.0005, 0.0002 respectively),significant negative correlation with ejection fraction (P = 0.04).
Conclusion: Measuring plasma concentration of BNP, may be useful for the identification of CKD patients with abnormal left ventricular Geometry.
Recommendations: Routine echocardiography is recommended in early stages of CKD.

DOI

10.21608/geget.2021.49731.1017

Keywords

Left ventricular geometry, NT pro BN, Chronic Kidney Disease, End Stage Renal Disease, Echocardiography

Authors

First Name

Bahia

Last Name

Moustafa

MiddleName

-

Affiliation

Department of Pediatrics, Pediatric Nephrology & Transplantation Unit, Cairo University, Kasr Al Ainy Faculty of Medicine, Egypt.

Email

moustafa_afpna@hotmail.com

City

Cairo

Orcid

0000_0003_1343_1013

First Name

Hala

Last Name

Hamza

MiddleName

-

Affiliation

Department of Pediatrics, Pediatric Cardiology Unit, Cairo University, Kasr Al Ainy Faculty of Medicine, Cairo, Egypt.

Email

dr.hala_hamza@hotmail.com

City

Cairo

Orcid

-

First Name

Abbas

Last Name

Mourad

MiddleName

-

Affiliation

Department of Pediatrics, Medical Research Division and Medical Research Centre of Excellence (MRCE), National Research Centre, Cairo, Egypt.

Email

amourad000@yahoo.com

City

Cairo

Orcid

-

First Name

Mohamed

Last Name

Shouman

MiddleName

-

Affiliation

Department of Pediatrics, Medical Research Division and Medical Research Centre of Excellence (MRCE), National Research Centre, Cairo, Egypt.

Email

mohsho1963@yahoo.com

City

Cairo

Orcid

0000-0002-8991-9165

First Name

Amany

Last Name

Ismail

MiddleName

Abdel Ghany

Affiliation

Department of Clinical Pathology, Medical Division, National Research Centre, Cairo, Egypt.

Email

amanyismaeil@hotmail.com

City

Cairo

Orcid

-

First Name

Rania

Last Name

Hegazy

MiddleName

-

Affiliation

Department of Pediatrics, Pediatric Cardiology Unit, Cairo University, Kasr Al Ainy Faculty of Medicine, Cairo, Egypt.

Email

r_hegazy@hotmail.com

City

Cairo

Orcid

-

First Name

Mohamed

Last Name

Zayed

MiddleName

-

Affiliation

Department of Pediatrics, Medical Research Division and Medical Research Centre of Excellence (MRCE), National Research Centre, Cairo, Egypt.

Email

mozayed2001@yahoo.com

City

Cairo

Orcid

-

Volume

15

Article Issue

2

Related Issue

20384

Issue Date

2020-12-01

Receive Date

2020-11-14

Publish Date

2020-12-01

Page Start

1

Page End

14

Print ISSN

1687-613X

Online ISSN

2636-3666

Link

https://geget.journals.ekb.eg/article_146337.html

Detail API

https://geget.journals.ekb.eg/service?article_code=146337

Order

1

Type

Original Article

Type Code

675

Publication Type

Journal

Publication Title

GEGET

Publication Link

https://geget.journals.ekb.eg/

MainTitle

-

Details

Type

Article

Created At

22 Jan 2023