A girl infant aged two months from Aswan complaining of abdominal distention and colic. Repeated attacks of vomiting and diarrhea .Multiple skin rashes distributed over the skull and the body, which are vivid superficial tiny masses known as capillary hemangioma. Also, there was heard murmur over the heart. Laboratory investigation and abdominal ultrasonography were done .There was anemia. Normal liver enzymes and liver functions: normal PT hypoalbuminemia. Abdominal ultrasound revealed hepatomegaly with multiple hypo echoic masses of variable sizes at both right and left lobes of liver. Doppler study and Echocardiography revealed secondum ASD 6 mm in diameter and small restrictive PDA for follow up. Also, CT abdomen was done there was enlarged liver which studied by innumerable focal masses in the hepatic parenchyma with tendency to confluence. These masses display hpodense attenuation on the precontrast series .This imaging are classic for infantile Hemangioendothelioma Alpha fetoprotein was done. CT brain was normal. It was normal. Medical therapy with steroid and liver support together with follows up by clinical examination and ultrasonography.