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245915

The Association between Catalase Gene rs1001179 and rs769217 Polymorphisms and The Hepatocellular Carcinoma Risk in the Egyptian Patients

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Last updated: 24 Dec 2024

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Abstract

Using a thorough case-control design, we evaluated whether CAT SNPs were hepatocellular carcinoma (HCC) risk factors in the current study. Employing PCR-RFLP analysis, the genotypes of CAT rs1001179 and rs769217 were determined in 50 HCC-diagnosed patients and 50 healthy controls. CAT rs1001179 distributions revealed considerable variations between both groups, either in terms of allelic or genotypic distribution, since TT genotypes and the T allele differed significantly between the examined groups. Regarding the CAT rs769217, there were also significant differences in TT genotypes and T allele between the studied groups In Conclusion, the collected information characterized the CAT gene in HCC patients in Egypt for the first time and associations between CAT gene rs1001179 (262C/T) and CAT rs769217 (389C/T) and the propensity to HCC.

DOI

10.21608/eajbsc.2022.245915

Keywords

CAT gene, Hepatocellular carcinoma, single nucleotide polymorphisms, PCR-RFLP

Authors

First Name

Mohammad

Last Name

Elkhamy

MiddleName

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Affiliation

Molecular Biology Department, Genetic Engineering and Biotechnology Research Institute (GEBRI), University of Sadat City, Egypt.

Email

elkhamylab@gmail.com

City

-

Orcid

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First Name

Gamal

Last Name

Badra

MiddleName

-

Affiliation

Hepatology and Internal Medicine, National liver Institute, Minufiya University.

Email

-

City

-

Orcid

-

First Name

Moustafa

Last Name

Sakr

MiddleName

A.

Affiliation

Molecular Diagnostics and Therapeutics Department, Genetic Engineering and Biotechnology Research Institute (GEBRI), University of Sadat City, Egypt.

Email

-

City

-

Orcid

-

First Name

Amal

Last Name

Abdel Aziz

MiddleName

A.

Affiliation

Molecular Biology Department, Genetic Engineering and Biotechnology Research Institute (GEBRI), University of Sadat City, Egypt.

Email

-

City

-

Orcid

-

First Name

Mahmoud

Last Name

Lotfy

MiddleName

-

Affiliation

Molecular Biology Department, Genetic Engineering and Biotechnology Research Institute (GEBRI), University of Sadat City, Egypt.

Email

-

City

-

Orcid

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Volume

14

Article Issue

1

Related Issue

29927

Issue Date

2022-06-01

Receive Date

2022-04-18

Publish Date

2022-06-23

Page Start

475

Page End

487

Print ISSN

2090-0767

Online ISSN

2090-083X

Article File

EAJBSC_Volume 14_Issue 1_Pages 475-487.pdf

PDF . 669.1kB

Link

https://eajbsc.journals.ekb.eg/article_245915.html

Detail API

https://eajbsc.journals.ekb.eg/service?article_code=245915

Order

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Type

Original Article

Type Code

673

Publication Type

Journal

Publication Title

Egyptian Academic Journal of Biological Sciences. C, Physiology and Molecular Biology

Publication Link

https://eajbsc.journals.ekb.eg/

MainTitle

The Association between Catalase Gene rs1001179 and rs769217 Polymorphisms and The Hepatocellular Carcinoma Risk in the Egyptian Patients

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Type

Article

Created At

22 Jan 2023