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210018

Association of Cytomegalovirus Infection with the Sustenance of Autoimmune Response in Patients with Pemphigus Vulgaris

Article

Last updated: 03 Jan 2025

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Abstract

In genetically vulnerable people, the cytomegalovirus (CMV) could be a major cause of autoimmunity. Emerging evidence reveals that CMV proteins are ubiquitous in autoimmunity-affected tissues and that autoimmune reactions may be sustained by both molecular mimicry and viral antigens. This study looked at how in-vitro CMV antigen stimulation affected T cell immunity and cytokine responsiveness in pemphigus vulgaris (PV) patients. Compared to healthy people, CMV antigen caused an increase in CD4+ T cells, notably the memory subset, and CD8+CD45RO+ T cells in PV patients. The CMV antigen induced an increase in the production of IL-4 and IFN-γ by PV PBMCs. The single nucleotide polymorphism IFN-γ +874 (rs2430561) was found to have a significant correlation with PV illness in our cytokine polymorphism analysis. IFN-γ may over-activate the immune system, resulting in antibody-mediated acantholytic disease via abnormal cell-mediated and humoral immunological responses. CMV infection may be a rare factor that sustains or exacerbates autoimmunity in PV disease in a non-specific way, especially in genetically predisposed hosts. 

DOI

10.21608/eajbsc.2021.210018

Keywords

T cells, Cytokines, Polymorphism, Exacerbation, Autoimmune Response

Authors

First Name

Ali

Last Name

Alisaac

MiddleName

-

Affiliation

Department of Laboratory Medicine, Faculty of Applied Medical Sciences, Albaha University, Albaha, Saudi Arabia

Email

aalisaac@bu.edu.sa

City

-

Orcid

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Volume

13

Article Issue

2

Related Issue

26732

Issue Date

2021-12-01

Receive Date

2021-10-20

Publish Date

2021-12-01

Page Start

241

Page End

248

Print ISSN

2090-0767

Online ISSN

2090-083X

Article File

EAJBSC_Volume 13_Issue 2_Pages 241-248.pdf

PDF . 650.2kB

Link

https://eajbsc.journals.ekb.eg/article_210018.html

Detail API

https://eajbsc.journals.ekb.eg/service?article_code=210018

Order

19

Type

Original Article

Type Code

673

Publication Type

Journal

Publication Title

Egyptian Academic Journal of Biological Sciences. C, Physiology and Molecular Biology

Publication Link

https://eajbsc.journals.ekb.eg/

MainTitle

Association of Cytomegalovirus Infection with the Sustenance of Autoimmune Response in Patients with Pemphigus Vulgaris

Details

Type

Article

Created At

22 Jan 2023