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196250

Syzygium cumini (L) Extract Ameliorates Aluminium Chloride-Induced Acute Hepatic and Renal Toxicity in Rats

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Last updated: 24 Dec 2024

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Abstract

Aluminium (Al) is the most common metallic element associated with pathogenesis in humans and animals. This study was conducted to evaluate the ability of Syzygium cumini (L.) leaves extract in attenuating the acute toxicity of aluminium-induced hepatic and renal toxicity in rats. Male rats were received oral administration of AlCl3 (150mg/kg) followed by oral administration of S. cumini (250mg/kg) leaves extract for 14 days. Aluminium concentration, MDA, NO, glutathione, oxidative enzymes (catalase, superoxide dismutase, glutathione reductase and glutathione peroxidase) was measured in liver and kidney homogenate. In addition, we demonstrate the level of serum and liver AST, ALT, ALP and serum urea and creatinine. Compared to the control group, the animal that received Al showed a significant elevation in the tissue level of Al, MDA, NO and reduction in the level of glutathione and antioxidant enzymes. It also showed a marked increase in serum liver function enzymes, creatinine and urea. The combined treatment with S. cumini leaves extract caused restoration of the oxidative levels and upregulation in antioxidant enzymes as compared to Al-intoxicated rats. In addition, the administration of S. cumini extracts in rats after Al administration caused a decrease in cytokines TNF-α and IL- 6, Bax & caspase-3 expression, in addition, to an increase in antiapoptotic marker Bcl2 in liver and kidney homogenate. In conclusion, our study revealed that the treatment with S. cumini leaves extracts ameliorates hepatic and renal cells toxicity produced by Al exposure by elevating the antioxidant enzymes, antiapoptotic and anti-inflammatory activity.

DOI

10.21608/eajbsc.2021.196250

Keywords

Syzygium cumini (L.), aluminium, antioxidant, Antiapoptotic, Liver, kidney

Authors

First Name

Fatma Elzahraa

Last Name

Salem

MiddleName

Hussien

Affiliation

Zoology and entomology department, Faculty of Science, Helwan University, Cairo, Egypt.

Email

elzahraa.fatma@yahoo.com

City

Cairo

Orcid

-

Volume

13

Article Issue

2

Related Issue

26732

Issue Date

2021-12-01

Receive Date

2021-08-18

Publish Date

2021-12-01

Page Start

73

Page End

87

Print ISSN

2090-0767

Online ISSN

2090-083X

Article File

EAJBSC_Volume 13_Issue 2_Pages 73-87.pdf

PDF . 878.2kB

Link

https://eajbsc.journals.ekb.eg/article_196250.html

Detail API

https://eajbsc.journals.ekb.eg/service?article_code=196250

Order

6

Type

Original Article

Type Code

673

Publication Type

Journal

Publication Title

Egyptian Academic Journal of Biological Sciences. C, Physiology and Molecular Biology

Publication Link

https://eajbsc.journals.ekb.eg/

MainTitle

Syzygium cumini (L) Extract Ameliorates Aluminium Chloride-Induced Acute Hepatic and Renal Toxicity in Rats

Details

Type

Article

Created At

22 Jan 2023