The present study was carried out to evaluate the protective effects of curcumin on Cyclophosphamide-induced deleterious lipid profile in rats. Experimental rats were randomly divided into four groups of five rats each. Group 1: served as the control rats, Group 2: was administered daily curcumin at a dose (150 mg/kg b.wt).  Group 3: a single dose of cyclophosphamide (150 mg/kg, i.p.) intraperitoneal injection, Group 4: was injected with cyclophosphamide + curcumin along the experimental period (30 days). The results refer to a significant elevation of lipid parameters (cholesterol, triglyceride and LDL-C) while a significant decrease in some other parameters (HDL-C). On the 30 days in rats injected intraperitoneal with cyclophosphamide as compared to the control groups. The administration of the curcumin has beneficial and decrease side effects against the deleterious changes of CCl₄. Concluded that supplementation of curcumin reverted these abnormalities in the lipid levels to near normalcy after cyclophosphamide administration.