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173938

COVID-19: Variable Immune Response in Indian Population

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Last updated: 03 Jan 2025

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Abstract

With a year and a half into the COVID-19 pandemic, still, variance in terms of transmission and susceptibility of different populations/ethnicities to the disease remains an enigma. The clinical outcome of COVID-19 disease is poor in patients with associated morbidities; however, the reasons behind significant mortality of immuno‐competent healthy individuals attributed to fulminant infection remains to be elucidated. Generally, protective B and T cell-mediated immune responses seem to have a tilted balance causing a sustained inflammatory state in SARS-CoV-2 infected individuals. The genetic makeup of an individual is highly likely to play a major role in elicitation as well as the outcome of the immune response in COVID‐19 cases. The Indian response to COVID-19 indicates a potential influence of genetic background on host immune response pathways leading to decreased susceptibility and mortality to SARS-CoV-2 infection. Many host genes are involved in the entry and replication of SARS‐CoV‐2 and the subsequent host immune response. The current review discusses the potential cytokine gene polymorphisms prevalent in the Indian population that may influence the transmission, severity and mortality due to COVID‐19 infection. 

DOI

10.21608/eajbsc.2021.173938

Keywords

COVID-19, Immune Response, genetic makeup, Host gene polymorphism, mortality

Authors

First Name

Shukla

Last Name

Das

MiddleName

-

Affiliation

Department of Microbiology, University College of Medical Sciences (University of Delhi) & GTB Hospital, Delhi, India

Email

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City

-

Orcid

-

First Name

Chhavi

Last Name

Gupta

MiddleName

-

Affiliation

Northern Railways Central Hospital, Delhi, India

Email

-

City

-

Orcid

-

First Name

Naseem

Last Name

Akhter

MiddleName

-

Affiliation

Department of Laboratory Medicine, Faculty of Applied Medical Sciences, Albaha University, Albaha, Saudi Arabia

Email

naseem.du@gmail.com

City

-

Orcid

-

First Name

Charu

Last Name

Jain

MiddleName

-

Affiliation

Department of Microbiology, University College of Medical Sciences (University of Delhi) & GTB Hospital, Delhi, India

Email

-

City

-

Orcid

-

First Name

Sidharth

Last Name

Sonthalia

MiddleName

-

Affiliation

Skinnocence: The Skin Clinic & Research Centre, Gurugram, India

Email

-

City

-

Orcid

-

First Name

Saif

Last Name

Ahmad

MiddleName

-

Affiliation

Barrow Neurological Institute, Phoenix, Arizona USA

Email

-

City

-

Orcid

-

First Name

Sajad

Last Name

Dar

MiddleName

Ahmad

Affiliation

Research and Scientific Studies Unit, College of Nursing, Jazan University, Jazan, Saudi Arabia

Email

darsajad990@gmail.com

City

-

Orcid

-

Volume

13

Article Issue

1

Related Issue

20278

Issue Date

2021-06-01

Receive Date

2021-03-27

Publish Date

2021-05-23

Page Start

133

Page End

147

Print ISSN

2090-0767

Online ISSN

2090-083X

Article File

EAJBSC_Volume 13_Issue 1_Pages 133-147.pdf

PDF . 826.0kB

Link

https://eajbsc.journals.ekb.eg/article_173938.html

Detail API

https://eajbsc.journals.ekb.eg/service?article_code=173938

Order

11

Type

Original Article

Type Code

673

Publication Type

Journal

Publication Title

Egyptian Academic Journal of Biological Sciences. C, Physiology and Molecular Biology

Publication Link

https://eajbsc.journals.ekb.eg/

MainTitle

COVID-19: Variable Immune Response in Indian Population

Details

Type

Article

Created At

22 Jan 2023