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159944

The Variant Allele Frequency of the lncRNA Prostate Cancer-Associated Noncoding RNA 1 (PRNCR1) rs1456315 C/T Polymorphism in Saudi Population and Colorectal Cancer Risk

Article

Last updated: 03 Jan 2025

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Abstract

Single-nucleotide polymorphisms (SNPs) in long noncoding RNA (lncRNA) genes are associated with the onset and progression of multiple cancers in humans. These SNPs are potential biomarkers for predicting cancer risk. The variable frequency of the lncRNA prostate cancer-associated noncoding RNA 1 (PRNCR1) rs1456315 C/T polymorphism may affect different ethnic groups differently, however, the information lacks for the Saudi population. The aim of this study was to assess the allelic distribution and frequency of the PRNCR1 rs1456315 C/T polymorphism in the Saudi Arabian population, as well as compare it to other populations around the world. PUBMED (Medline) and other related web-databases were referred to extract data from epidemiological studies performed in different ethnic groups. The frequency of PRNCR1 rs1456315 variant allele (C) was found to be 34.62% and a significantly different frequency was observed for the USA (p=0.01), Iran (p < /em><0.007) and China (p=0.01) ethnicity, when the Saudi occurrence is compared to those populations. Present results reveal a distinct pattern of lncRNA prostate cancer-associated noncoding RNA 1 (PRNCR1) rs1456315 polymorphism variant allele in the Saudi Arabian population, which may be due to ethnic differences. The findings could assist in the risk assessment of people harbouring risk allele of rs1456315 SNP and their subsequent cancer susceptibility.

DOI

10.21608/eajbsc.2021.159944

Keywords

Cancer, PRNCR1, rs1456315, Single nucleotide polymorphism

Authors

First Name

Naseem

Last Name

Akhter

MiddleName

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Affiliation

Department of Laboratory Medicine, Faculty of Applied Medical Sciences, Albaha University, Albaha- KSA

Email

naseem.du@gmail.com

City

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Orcid

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Volume

13

Article Issue

1

Related Issue

20278

Issue Date

2021-06-01

Receive Date

2021-01-27

Publish Date

2021-03-29

Page Start

83

Page End

91

Print ISSN

2090-0767

Online ISSN

2090-083X

Article File

EAJBSC_Volume 13_Issue 1_Pages 83-91.pdf

PDF . 685.5kB

Link

https://eajbsc.journals.ekb.eg/article_159944.html

Detail API

https://eajbsc.journals.ekb.eg/service?article_code=159944

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7

Type

Original Article

Type Code

673

Publication Type

Journal

Publication Title

Egyptian Academic Journal of Biological Sciences. C, Physiology and Molecular Biology

Publication Link

https://eajbsc.journals.ekb.eg/

MainTitle

The Variant Allele Frequency of the lncRNA Prostate Cancer-Associated Noncoding RNA 1 (PRNCR1) rs1456315 C/T Polymorphism in Saudi Population and Colorectal Cancer Risk

Details

Type

Article

Created At

22 Jan 2023