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Possible Kefir Biological Effects: 4: Effect of Kefir Beverage on The Histopathological and Macroscopical Changes in Adipose Tissue of High Fat-Fed STZ- Induced Diabetic Male Wist

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Last updated: 03 Jan 2025

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Abstract

This study was designed to investigate the effect of kefir consumption as a common dairy fermented product on keep the bodyweight balanced on high fat-fed streptozotocin-induced diabetic wistar rats which fed with a daily kefir gavage dose, also to examine any effects regards the abdominal circumference (AC) and body fat mass; observed results compared to normal male rats; Experiments were carried out on 60 albino male rats, with age 8 weeks, weighing about 220-250 g, after the adaptation period, male rats were divided randomly into two experiments by six groups: experiment Ⅰ included 3 non-diabetic ones and experiment ⅠⅠ included three STZ induced diabetes groups. The groups were fed as follows: group 1 received a standard diet and served as control. Group 2 was fed on a standard diet and kefir (0.7 ml/animal/day by gavage). Group 3 received a high-fat diet and kefir (0.7 ml/animal/day by gavage). The diabetic males of groups A, B and C were fed on a high-fat diet. Group B received in addition kefir (0.7 ml/animal/day by gavage), while group C was injected additionally with insulin (0.76 UI/200 mg BW/day); all the groups have the access to the drinking water all the time.; the bodyweight of normal and diabetic rat males was determined on 1sttreatment day,and every week until the end the experiment plan (5 weeks) then all the groups were sacrificed with measuring the AC and weighting the fat mass; Summarizing it could be said; through all the work plan (5 weeks), all the six animal groups showed a significant increase in the mean body weight with a normal level in experiment Ⅰ unless in group 3 which fed on HFD and kefir, while in experiment ⅠⅠ kefir helps the diabetic treated group to not losing weight compared to the untreated one; similarity kefir neither affect AC nor relative fat weight.

DOI

10.21608/eajbsc.2020.78931

Keywords

diabetes, High fat diet, Kefir, Insulin, Bodyweight, Wistar rat, cell biology, histopathology, physiology

Authors

First Name

Abdel-Baset

Last Name

Aref

MiddleName

M.

Affiliation

Zoology Department, Faculty of Science, South Valley University, Egypt. IACUC of SVU in Egypt

Email

aref322189@yahoo.com

City

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Orcid

-

First Name

Margit

Last Name

Semmler

MiddleName

-

Affiliation

Diabetes Research Institute, Düsseldorf University, Düsseldorf, Germany

Email

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City

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Orcid

-

First Name

Osama

Last Name

Ahmed

MiddleName

M.

Affiliation

Physiology Division, Zoology Department, Faculty of Science, Beni-Suef University, Salah Salem Street, P.O. Box 62514, Beni-Suef, Egypt

Email

-

City

-

Orcid

-

First Name

G.

Last Name

Ünlü

MiddleName

-

Affiliation

Microbiology Departiment School of Food Science, Idaho University, USA

Email

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City

-

Orcid

-

First Name

Lobna

Last Name

Ali

MiddleName

A.

Affiliation

Cell Biology and Histochemistry Division, Zoology Department, Faculty of Science, South Valley University, Qena, Egypt. IACUC of SVU in Egypt

Email

-

City

-

Orcid

-

First Name

Mohie

Last Name

Haridy

MiddleName

-

Affiliation

Pathology Department, Clinical Pathology, Faculty of Veterinary Medicine, South Valley University

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-

City

-

Orcid

-

Volume

12

Article Issue

1

Related Issue

10288

Issue Date

2020-06-01

Receive Date

2020-01-12

Publish Date

2020-06-01

Page Start

51

Page End

63

Print ISSN

2090-0767

Online ISSN

2090-083X

Link

https://eajbsc.journals.ekb.eg/article_78931.html

Detail API

https://eajbsc.journals.ekb.eg/service?article_code=78931

Order

5

Type

Original Article

Type Code

673

Publication Type

Journal

Publication Title

Egyptian Academic Journal of Biological Sciences. C, Physiology and Molecular Biology

Publication Link

https://eajbsc.journals.ekb.eg/

MainTitle

Possible Kefir Biological Effects: 4: Effect of Kefir Beverage on The Histopathological and Macroscopical Changes in Adipose Tissue of High Fat-Fed STZ- Induced Diabetic Male Wistar Rat

Details

Type

Article

Created At

22 Jan 2023