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33962

Reduction in the Formation of Micronucleated Polychromatic Erythrocytes Induced by Cisplatin in Bone Marrow Cells of Rats by using Antioxidants.

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Last updated: 22 Jan 2023

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Abstract

Cisplatin is extensively used as a main chemotherapeutic drug for the treatment of many types of tumors. Cisplatin exerts excellent anticancer action, but its clinical use is frequently limited due to the development of severe side effects in the treated patients such as nephrotoxicity, anemia and bone marrow damage. Cytotoxicity of cisplatin is closely related to the generation of reactive oxygen species leading to oxidation of vital components of the cell (DNA) and genomic instability. Results and Conclusion: The results supported that the combination between curcumin and vitamin C (with more adjusted dose of vitamin C) exerted the best ameliorative effect against the cisplatin induction of micronucleated polychromatic erythrocytes.                                         

DOI

10.21608/eajbsc.2019.33962

Keywords

Cisplatin, vitamin c, Curcumin, Micronucleated polychromatic erythrocytes, Micronucleus test, antioxidants

Authors

First Name

Fawzyea

Last Name

Zaied

MiddleName

Abdelhady

Affiliation

Zoology Department, Faculty of Science, Zagazig University, Zagazig, Egypt.

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City

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Orcid

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First Name

Sabha

Last Name

Elballat

MiddleName

Elsayed

Affiliation

Zoology Department, Faculty of Science, Zagazig University, Zagazig, Egypt.

Email

sabhael@zu.edu.eg

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Orcid

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Volume

11

Article Issue

2

Related Issue

5098

Issue Date

2019-03-01

Receive Date

2019-03-02

Publish Date

2019-03-01

Page Start

47

Page End

55

Print ISSN

2090-0767

Online ISSN

2090-083X

Article File

EAJBSC_Volume 11_Issue 2_Pages 47-55.pdf

PDF . 1.4MB

Link

https://eajbsc.journals.ekb.eg/article_33962.html

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https://eajbsc.journals.ekb.eg/service?article_code=33962

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Original Article

Type Code

673

Publication Type

Journal

Publication Title

Egyptian Academic Journal of Biological Sciences. C, Physiology and Molecular Biology

Publication Link

https://eajbsc.journals.ekb.eg/

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Article

Created At

22 Jan 2023