Background: Several efforts have been made to reduce the burden of CKD through the control of its associated risk factors. The objective of this study was to assess, whether the biochemical, electrolytes and calcium values differ according to the sex of the patients, as well as, the possible association between UMOD gene mutation and certain patterns of biochemical, electrolytes and calcium measures. Methodology: one hundred patients with CKD were randomly selected from different primary health care centers (PHCs) in the Kingdom of Saudi Arabia (KSA). Biochemical (Creatinine, Urea, Uric acid, and Glucose) and minerals (Na+, K+, Cl− and Ca++) values were estimated, and UMOD gene mutations were investigated. Results: About 71.9% of the males were found with high urea values compared to 33.3% of the females, the RR (95% CI) = 2.1563 (1.3253 to 3.5082), P = 0.0020. Low K+ levels were significantly associated with females compared to males, the RR (95% CI) = 2.819 (1.1066 to 5.0773), P = 0.0264. About 60% 80% and 100% of the patients with UMOD gene mutation were found with low Na+ uric acid and Ca++. Conclusion: High blood urea is suggested as screening predictor for CKD in males. Low K+ levels were significantly associated with females compared to males. Patients with UMOD gene associated CKD are more susceptible to be with low serum Uric acid, Sodium, and Calcium