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26817

Cathepsin L is A Potential Marker for Triple-Negative Breast Cancer

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Last updated: 22 Jan 2023

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Abstract

Breast cancer is the second cancer-related death among women worldwide. Triple-negative breast cancer (TNBC) is the most aggressive and lethal subtype, which is associated with high metastasis and poor prognosis. Cathepsins, a family of lysosomal cysteine proteases, such as cathepsin L (CTSL), are involved in cancer invasion and metastasis. Thus, CTSL may emerge as a marker for TNBC. So, we characterized the expression of CTSL mRNA in tissue specimen of TNBC (n = 10) and non-TNBC (non-TN) (n = 10) using quantitative real-time PCR. Data were statistically analyzed using Mann-Whitney U-test. Our data demonstrate that CTSL mRNA expression was up-regulated in TN BC vs. non-TN BC patients. In conclusion, the high expression of CTSL may represent a marker for TNBC and its targeting could have therapeutic implications

DOI

10.21608/eajbsc.2019.26817

Keywords

Triple-negative, breast cancer, Cathepsin L

Authors

First Name

Mennatullah

Last Name

El-Nadi

MiddleName

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Affiliation

Department of Zoology, Faculty of Science, Cairo University, Cairo University, Giza, 12613, Egypt

Email

quranii_nourii@yahoo.com

City

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Orcid

-

First Name

Hebatallah

Last Name

Hassan

MiddleName

-

Affiliation

Department of Zoology, Faculty of Science, Cairo University, Cairo University, Giza, 12613, Egypt

Email

heba4381@yahoo.com

City

-

Orcid

-

First Name

Mahmoud

Last Name

Amer

MiddleName

-

Affiliation

Department of Zoology, Faculty of Science, Cairo University, Cairo University, Giza, 12613, Egypt

Email

-

City

-

Orcid

-

First Name

Mona

Last Name

Mohamed

MiddleName

Mostafa

Affiliation

Department of Zoology, Faculty of Science, Cairo University, Cairo University, Giza, 12613, Egypt

Email

-

City

-

Orcid

-

First Name

Mohamed

Last Name

El-Shinawi

MiddleName

-

Affiliation

Department of General Surgery, Faculty of Medicine, Ain Shams University, Cairo, 11566, Egypt

Email

-

City

-

Orcid

-

First Name

Sherif

Last Name

Ibrahim

MiddleName

Abdelaziz

Affiliation

Department of Zoology, Faculty of Science, Cairo University, Cairo University, Giza, 12613, Egypt

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-

City

-

Orcid

-

Volume

11

Article Issue

1

Related Issue

4736

Issue Date

2019-06-01

Receive Date

2019-01-03

Publish Date

2019-06-01

Page Start

29

Page End

36

Print ISSN

2090-0767

Online ISSN

2090-083X

Article File

EAJBSC_Volume 11_Issue 1_Pages 29-36.pdf

PDF . 725.1kB

Link

https://eajbsc.journals.ekb.eg/article_26817.html

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https://eajbsc.journals.ekb.eg/service?article_code=26817

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Original Article

Type Code

673

Publication Type

Journal

Publication Title

Egyptian Academic Journal of Biological Sciences. C, Physiology and Molecular Biology

Publication Link

https://eajbsc.journals.ekb.eg/

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Article

Created At

22 Jan 2023