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Anti-nephrotoxic and Antioxidant Efficiency of Rosmarinus Officinalis Extract Against Isoniazid®-Induced Nephropathy in Adult Male Albino Rats.

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Last updated: 03 Jan 2025

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Abstract

Tuberculosis accounted as a serious disease throughout the world, and nephrotoxicityis one of the most serious side effects of main anti-tuberculosis drugs. The objective of this study was to explore the nephro-protective potential of rosemary aqueous extract against Isoniazid®-induced nephrotoxicity. Adult male Wistar albino rats (150-170g) were randomly divided into four groups: 1) normal rats, 2) rats administrated with rosemary extract (440mg/kg/day), 3) rats received Isoniazid® (50mg/kg/day), and 4) rats treated with Isoniazid® in combination with rosemary extract. After eight weeks, the results revealed that rosemary extract along with Isoniazid® minimized the Isoniazid®-induced renal deterioration; this was evidenced by the significant reduction in serum levels of urea, creatinine, uric acid, TNF-α, IL-1β and Na+ as well as kidney MDA, nitric oxide and DNA fragmentation .This was matched with  a marked enhancement in calcium and K+ serum levels. and so kidney GSH, and Na+/K+ ATPase activity. Moreover, the histopathological findings showed a potential protection as the extract succeeded in prevention of Isoniazid® induced tissue degenerations. In conclusion, rosemary extract could play a beneficial role for the prevention of Isoniazid®-nephrotoxicity via its anti-oxidative and anti-nitrosative voltage.

DOI

10.21608/eajbsc.2018.22667

Keywords

tuberculosis, Isoniazid® (INH), Nephrotoxicity, rosemary, Rats

Authors

First Name

Mahmoud

Last Name

Ashry

MiddleName

-

Affiliation

Zoology Department, Faculty of Science, Al-Azhar University, Egypt

Email

mahmoud_ashry20@yahoo.com

City

-

Orcid

-

First Name

Mohamed

Last Name

Mustafa

MiddleName

A.

Affiliation

Basic Centre of Science, Misr University for Science and Technology, Egypt

Email

-

City

-

Orcid

-

First Name

Hagar

Last Name

Mourad

MiddleName

H.

Affiliation

Medical Physiology Department, National Research Centre, Egypt

Email

-

City

-

Orcid

-

First Name

Mahitab

Last Name

EL-Kassaby

MiddleName

I.

Affiliation

Medical Physiology Department, National Research Centre, Egypt

Email

-

City

-

Orcid

-

First Name

Fatma

Last Name

Morsy

MiddleName

Adly

Affiliation

Pathology Department, National Research Centre, Egypt

Email

-

City

-

Orcid

-

First Name

Sayed

Last Name

N.

MiddleName

O.

Affiliation

Chemistry Department, Fayoum University, Cairo, Egypt

Email

-

City

-

Orcid

-

First Name

Khaled

Last Name

Abdel-Wahhab

MiddleName

G.

Affiliation

Medical Physiology Department, National Research Centre, Egypt

Email

-

City

-

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-

Volume

10

Article Issue

2

Related Issue

4296

Issue Date

2018-12-01

Receive Date

2018-12-23

Publish Date

2018-12-01

Page Start

45

Page End

61

Print ISSN

2090-0767

Online ISSN

2090-083X

Article File

EAJBSC_Volume 10_Issue 2_Pages 45-61.pdf

PDF . 996.3kB

Link

https://eajbsc.journals.ekb.eg/article_22667.html

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https://eajbsc.journals.ekb.eg/service?article_code=22667

Order

5

Type

Original Article

Type Code

673

Publication Type

Journal

Publication Title

Egyptian Academic Journal of Biological Sciences. C, Physiology and Molecular Biology

Publication Link

https://eajbsc.journals.ekb.eg/

MainTitle

Anti-nephrotoxic and Antioxidant Efficiency of Rosmarinus Officinalis Extract Against Isoniazid®-Induced Nephropathy in Adult Male Albino Rats.

Details

Type

Article

Created At

22 Jan 2023