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22663

Comparative Biochemical Studies on the Effect of Nano-Magnetic Particles (Nps) and Graviola Leaves Extract on Adriamycin Induced-Gonadotoxicity in Male Albino Rats

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Last updated: 22 Jan 2023

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Abstract

Adriamycin (ADR) is an effective antineoplastic agent commonly used to treat different types of cancer. The use of ADR in clinical chemotherapy is limited due to diverse toxicities, including gonadotoxicity. The present study was designed to evaluate the effect of nano-magnetic particles (NFe3O4) and Graviola leaves extract and (NFe3O4 + Graviola leaves extract) against ADR -induced gonadotoxicity. The rats divided into 5 groups (10 rats per group). The first group (normal g.), the second group received ADR alone (5 mg/kg body weight, i.p.) as (control g.), the third group received ADR followed by NFe3O4 (5 mg/kg body weight, i.p.), the fourth group received ADR followed by Graviola (200mg/kg body weight, orally), and the fifth group received ADR followed by NFe3O4(5 mg/kg body weight, i.p.) and Graviola leaves extract(200mg/kg body weight, orally). Animals were sacrificed 36 days after treatment and sex hormones (Testosterone and F.S.H) in serum. Also, the activities of antioxidants such as (SOD), (CAT), (GSH) and the level of (MDA) as a marker of lipid peroxidation were measured. In the ADR-exposed rats, Testosterone, F.S.H, GSH, SOD and CAT were significantly decreased, while MDA was significantly increased.When compared with normal animals. In the Group NFe3O4, graviola, and (NFe3O4 +graviola), Testosterone, F.S.H, GSH, SOD and CAT enzymes levels were significantly increased, while MDA level was significantly decreased when compared with ADR treated animals. The results showed that there is a possibility that the ethanolic extract of graviola leaves and NFe3O4 ameliorate the gonadotoxicity induced by ADR in rats.

DOI

10.21608/eajbsc.2018.22663

Keywords

Adriamycin, Iron oxide nanoparticles, graviola leaves extract, gonadotoxicity, Antioxidant enzymes, serum hormones, Rats

Authors

First Name

Abd-Elraheim

Last Name

Elshaterˡ

MiddleName

A.

Affiliation

Department of Zoology, Faculty of Science, South Valley University, Qena, Egypt

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City

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Orcid

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First Name

Rana

Last Name

Aliˡ

MiddleName

A.

Affiliation

Department of Zoology, Faculty of Science, South Valley University, Qena, Egypt

Email

rana.ahmed@sci.svu.edu.eg

City

-

Orcid

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First Name

Mouchira

Last Name

Mohi

MiddleName

M.

Affiliation

Department of Pathology, Faculty of Veterinary Medicine, South Valley University, Qena, Egypt

Email

-

City

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Orcid

-

First Name

Huda

Last Name

Gedawy

MiddleName

Y.

Affiliation

Department of Zoology, Faculty of Science, South Valley University, Qena, Egypt

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-

City

-

Orcid

-

Volume

10

Article Issue

2

Related Issue

4296

Issue Date

2018-12-01

Receive Date

2018-12-23

Publish Date

2018-12-01

Page Start

11

Page End

25

Print ISSN

2090-0767

Online ISSN

2090-083X

Article File

EAJBSC_Volume 10_Issue 2_Pages 11-25.pdf

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https://eajbsc.journals.ekb.eg/article_22663.html

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https://eajbsc.journals.ekb.eg/service?article_code=22663

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Original Article

Type Code

673

Publication Type

Journal

Publication Title

Egyptian Academic Journal of Biological Sciences. C, Physiology and Molecular Biology

Publication Link

https://eajbsc.journals.ekb.eg/

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Article

Created At

22 Jan 2023