Whole body gamma irradiation of growing male Guinea pigs at the dose of 150 rads/animal reduced the levels of total protein and albumin.  Growing Guinea pigs males (250 ± 30 gm. b. w.) were divided into two main groups; non-irradiated and irradiated groups and every main group were divided into four sub-groups. Irradiated growing Guinea pigs males groups were exposed to 150 Rads/animal by cesium-137 irradiation unit with a dose route of 1.06483 rad per second in a uniform manner and divided into four sub-groups. In irradiated groups; the first sub-groups were interaperitoneally (i.p) injected with100 µL saline solution. The second sub-groups were i.p. injection of bone marrow cells from their twins (2.5x10⁶ cells/animall). The third sub-groups injected i. p with BPF (1µgm/gm. b. w.) which was dissolved in saline solution. The fourth sub-group injected with i.p solution of BPF (1µg/gm. b. w.) together with bone marrow cells from their twins (2.5x10⁶ cells/animal). The non-irradiated sub-groups were injected with the same manner of irradiated sub-groups. The level of total protein and albumin in serum were measured at periods of 1, 3, 7, 14 and 21 days. Irradiated animals i.p. injection of BPF (single dose); appears slight to improve the changes which occurred in both total protein and albumin compared to irradiated sub-group. However, irradiated Guinea pigs injected with single dose of BPF together with bone marrow cells were more improvement of these parameters than sub-groups injected with only single dose of BPF. The improvement of these parameters may be attributed to stimulate growth factors and/or growth hormones to increase protein synthesis as an effect on the liver that necessitates future investigations.