Objective: to evaluate the clinical and diagnostic significant of lp (a) levels and other lipid and apolipoprotein profiles in diabetic patients compared with different categorization of diabetic patients. Method: Case control study determined the levels of lp (a), apolipoprotein A1, apolipoprotein B, Total Cholesterol (TC), Triglyceride (TG), Low Density Lipoprotein (LDL), High Density Lipoprotein (HDL) and fibrinogen in 100 diabetic patients with both types (40 were Insulin Dependent Diabetic Mellitus, IDDM and 60 were Non-Insulin Dependent Diabetic Mellitus NIDDM) and compared with normal healthy subjects. Results: lp (a), apolipoprotein B, TC, TG and LDL were significantly higher in patients than control healthy subjects (p<0.05), apolipoprotein A1 and HDL were significantly lower in patients than control healthy subjects (p<0.05). No significant difference found in Fibrinogen between patients and controls. Lp (a) levels in obese patients significantly higher than in normal weight (p<<0.05). lp (a)  in patients with Coronary Heart Disease (CHD) was significantly higher than patients without CHD (p<0.05). Lp (a) was significantly higher in NIDDM than in IDDM (p<0.05). Conclusion: The study confirmed that the Lp (a) and other lipid and apolipoprotein parameters were significantly raised (good lipid decreased (apo A1 and HDL)) in diabetic patients compared to healthy subjects, and lp (a) are important diagnostic marker that can be used for early detection of atherosclerotic cardiovascular disease (CVD) in diabetic patients.