The present study aimed to investigate the  potential protective effects of lycopene (9 mg/kg ) in comparison with vitamin E (50 mg/kg) against the impacts of lead (Pb) toxicity(7 mg/l: 1/4 of 96 h LC50) on fishes Pb exposed for 15 and 30 days. Pb impacts were evaluated in terms of haematological and biochemical characteristics. The activities of aspartate aminotransferase and alanine aminotransferase in serum were significantly increased due to Pb. Treatment with Pb caused a significant increase in mean corpuscular haemoglobin concentration, serum glucose, total lipid,urea and creatinine and Lipid peroxidation in liver,kidney and gills tissues. On the other hand, Pb significantly caused decline in serum total protein,albumin, blood haemoglobin, red blood cell count, haematocrit value, mean corpuscular volume and mean corpuscular haemoglobin . It was observed that supplementation of lycopene and vitamin E decreases the toxic effect of lead.