Background: Various hemostatic abnormalities can occur in patients with liver disease, the severity of these abnormalities is dependent on the degree of hepatic dysfunction.  Liver disease can cause both quantitative and qualitative abnormalities in coagulation factors, fibrinolytic system and platelets abnormalities, with consequent variable impairment of coagulation parameters. Methods: In this case control study we examined the 60 liver diseases patients and 30 control healthy subjects, in Khartoum Teaching Hospital (Khartoum, Sudan) during the period 10/3/2012 to 12/6/2012. Prothrombin time (PT), Activated partial Thrmboplastine time (APTT) and fibrinogen level (FL) were determined and categorized by types of liver disease, age, and sex in all study subjects. Results: The result revealed that there were significant increased in (PT) (P=0.00), APTT (P=0.00) and significant decreased in fibrinogen level (P=0.00) among patients of liver disease when compared with control group.  There were no significant changes in coagulation parameters related to age and gender.  Conclusion: There were significant increased in PT and APTT associated with liver diseases and significant decreased in fibrinogen level among patients of liver disease when compared to normal control.