Beta
ManageSearchChatDiscover
16047

The curative effect of Bee Venom and Propolis on oxidative stress induced by γ-irradiation on blood and tissues of rats

Article

Last updated: 22 Jan 2023

OverviewSimilar Items

Subjects

-

Tags

-

Abstract

The biological effects of ionizing radiation
result in the formation of free radicals which are the main cause of cellular
damage. This study was aimed to detect the curative effect of some antioxidants
drugs (Bee venom and Propolis) on the hematological, biochemical and histological
parameters after exposed to γ-irradiation on the rats. Five groups of adult
male albino rats were established (n= 11). The first group (Gp. 1) was served
as normal group. Gp. 2 was exposed the whole body of rats to a single shot dose
of gamma radiation (5Gy) and served as control group. Gp. 3 was injected
intraperitoneal (i.p.) daily with Bee venomat dose (5ml/kgbody weight). Gp. 4 was given orally Propolis daily at dose 300 mg/kg body weight (B.wt). Gp. 5 was administered of (5ml/kgbody weight) of Bee
venom injected i.p. plus orally 300 mg/kg (B.wt) of Propolis, daily. All groups were treated after 8 hours exposure,
for 40 day. Whole blood, serum and biopsy from liver and kidneys were collected
for hematological, biochemical and histopathological examinations,
respectivetly. In the irradiated group (gp. 2), hematotoxicity was determined
by a significant decrease in red blood cells (RBCs), white blood cells (WBCs),
blood Platelets (PLTs), haemoglobin (Hb) and PCV value, as well as there are an elevation in serum
ALT, AST, ALP, LDH, creatinine and urea, associated with reduction in albumin
and uric acid. Hepatotoxicity was recorded in a highly significant increase
malondialdehyde (MDA) with marked reduction in glutathione (GSH) levels,
superoxide dismutase (SOD) and catalase (CAT) activities. In addition to,
degenerative and necrotic changes showed in liver and kidneys. It could be
concluded that Bee venom and Propolis, clarified a modulatory role against the
cellular damage produced by free radicals induced by ionizing radiation.

DOI

10.21608/eajbsc.2014.16047

Keywords

Bee venom, Propolis, Oxidative Stress, γ-irradiation, Rats

Authors

First Name

Abd-Elraheim

Last Name

Elshater

MiddleName

A.

Affiliation

Zoology Department, Faculty of Science;

Email

-

City

-

Orcid

-

First Name

Mouchira

Last Name

Mohi Eldin

MiddleName

M.

Affiliation

Pathology and Clinical Pathology Department, Faculty of Vet. Med., South Valley University, Qena, 83523

Email

-

City

-

Orcid

-

First Name

Muhammad

Last Name

Salman

MiddleName

M. A.

Affiliation

Pathology and Clinical Pathology Department, Faculty of Vet. Med., South Valley University, Qena, 83523

Email

salman2_52014@yahoo.com

City

-

Orcid

-

First Name

Naglaa

Last Name

Kasem

MiddleName

R. A.

Affiliation

Pathology and Clinical Pathology Department, Faculty of Vet. Med., South Valley University, Qena, 83523

Email

-

City

-

Orcid

-

Volume

6

Article Issue

1

Related Issue

3452

Issue Date

2014-06-01

Receive Date

2018-10-06

Publish Date

2014-06-01

Page Start

53

Page End

69

Print ISSN

2090-0767

Online ISSN

2090-083X

Article File

EAJBSC_Volume 6_Issue 1_Pages 53-69.pdf

PDF . 528.3kB

Link

https://eajbsc.journals.ekb.eg/article_16047.html

Detail API

https://eajbsc.journals.ekb.eg/service?article_code=16047

Order

6

Publication Type

Journal

Publication Title

Egyptian Academic Journal of Biological Sciences. C, Physiology and Molecular Biology

Publication Link

https://eajbsc.journals.ekb.eg/

MainTitle

-

Details

Type

Article

Created At

22 Jan 2023