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16043

Hepatitis B Vaccine Reduced the Prevalence of Antibodies to Hepatitis B Core Antigen in Blood Donors in Aseer Region,Saudi Arabia

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Last updated: 03 Jan 2025

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Abstract

Viral hepatitis is one of the major problem
worldwide. The detection of hepatitis B virus (HBV) surface antigen (HBsAg),
antibodies to HBV core antigen (HBc-Ab), and HBV-DNA in donated blood in Aseer
Region (Southern part of Kingdom of Saudi Arabia) to detect prevention of the
residual risk of transfusion transmitted HBV, donors in window period of HBV
infection and the prevalence of HBV infection was attempted. The study was
conducted on random blood samples collected from healthy blood donor
volunteers, who were referred to blood transfusion centers found at Aseer region,
during the period from March 2012 to January 2013. All the collected blood
units were screened for hepatitis B surface antigen (HBsAg), anti-HBc,
hepatitis C virus (HCV), human immunodeficiency virus (HIV) 1 and 2, human
T-cell lymphotropic virus (HTLV) I/II, venereal disease research laboratory
(VDRL), and malaria. All donated blood samples were checked for HBV-DNA,
HCV-RNA, and HIV-RNA by nucleic acid test (NAT) technology. Of 6698 (19 females
(0.28%) and 6679 males (99.72)) blood donors screened, with median age of 28
(female) and 30 years (males), 69 (1.03%) were HBsAg positive of them 64 (0.96)
were positive to HBV-DNA, 411 (6.14%) were anti-HBc positive of them 73 (1.09%)
were positive to HBV-DNA. Cases positive to both HBsAg and HBc-Ab were 68 (1.02%)
of them 63 (0.94%) were positive to HBV-DNA. All HBsAg and HBc-Ab positive
cases were shown to be among male volunteers. In conclusion, prevalence of
HBsAg in Asser region is very low. The rate of HBc-Ab in units of blood
donation is relatively high. The presence of HBV-DNA in HBc-Ab positive
donations makes it risky for use. Vaccination program against HBV decreased the
rate of HBV transmission.

DOI

10.21608/eajbsc.2014.16043

Keywords

Blood Bank, HBV, HBsAg, HBc-Ab, Hepatitis B vaccination

Authors

First Name

Essam

Last Name

Ibrahim

MiddleName

H.

Affiliation

- Department of Biology, Faculty of Science, King Khalid University, Abha, P.O. Box 9004, Saudi Arabia - Department of Blood Products Quality Control and Research, National Organization for Research and Control of Biologicals, Cairo, Egypt.

Email

essamebrahim@hotmail.com

City

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Orcid

-

First Name

Saad

Last Name

Bin Dajem

MiddleName

M.

Affiliation

Department of Biology, Faculty of Science, King Khalid University, Abha, P.O. Box 9004, Saudi Arabia

Email

-

City

-

Orcid

-

First Name

Abdulaziz

Last Name

Heijan

MiddleName

A

Affiliation

Blood Bank, Aseer Central Hospital, Abha, Saudi Arabia

Email

-

City

-

Orcid

-

First Name

Hala

Last Name

Hadish

MiddleName

F.

Affiliation

- Blood Bank, Aseer Central Hospital, Abha, Saudi Arabia - Department of Hematology, Teshreen Hospital, Damascus, Syria

Email

-

City

-

Orcid

-

First Name

Yasser

Last Name

Zahar

MiddleName

A.

Affiliation

Blood Bank, Abha General Hospital, Abha , Saudi Arabia

Email

-

City

-

Orcid

-

First Name

Ali

Last Name

Alshehri

MiddleName

-

Affiliation

Department of Biology, Faculty of Science, King Khalid University, Abha, P.O. Box 9004, Saudi Arabia

Email

-

City

-

Orcid

-

First Name

Mona

Last Name

Kilany

MiddleName

-

Affiliation

- Department of Microbiology, National Organization for Drug Control and Research (NODCAR), Cairo, Egypt

Email

-

City

-

Orcid

-

First Name

Osama

Last Name

Mostafa

MiddleName

M. S.

Affiliation

Department of Zoology, Faculty of Science, Ain Shams University, Abbassia 11566, Cairo, Egyp

Email

-

City

-

Orcid

-

Volume

6

Article Issue

1

Related Issue

3452

Issue Date

2014-06-01

Receive Date

2018-10-06

Publish Date

2014-06-01

Page Start

13

Page End

22

Print ISSN

2090-0767

Online ISSN

2090-083X

Article File

EAJBSC_Volume 6_Issue 1_Pages 13-22.pdf

PDF . 237.1kB

Link

https://eajbsc.journals.ekb.eg/article_16043.html

Detail API

https://eajbsc.journals.ekb.eg/service?article_code=16043

Order

2

Type

Original Article

Type Code

673

Publication Type

Journal

Publication Title

Egyptian Academic Journal of Biological Sciences. C, Physiology and Molecular Biology

Publication Link

https://eajbsc.journals.ekb.eg/

MainTitle

Hepatitis B Vaccine Reduced the Prevalence of Antibodies to Hepatitis B Core Antigen in Blood Donors in Aseer Region,Saudi Arabia

Details

Type

Article

Created At

22 Jan 2023