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16041

The effect of chloroquine induced hypoglycemia on the levels of major blood serum proteins in diabetic mice

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Last updated: 03 Jan 2025

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Abstract

Chloroquine is a drug derived from cinchona bark has been used for long
time to treat different diseases including malaria and accidently it was proved
to lower hyperglycemia. Diabetes mellitus is accompanied with many disorders
including blood serum proteins levels. Taking into consideration that insulin
administration controls hyperglycemia of diabetic patients but it is not
sufficient to restore the level of blood serum proteins. In the present work we
compared the action of chloroquine and insulin on major blood serum proteins of
alloxan induced diabetes. Mice were injected once with alloxan and then treated
either with chloroquine or insulin. Another category of mice were fed with high
glucose diet for short or long period to induce hyperglycemia independent of
insulin level. Major blood serum proteins namely; transferrin, albumin,
antitrypsin, acid glycoprotein and immunoglobulin G were estimated by SDS-PAGE
and Image J software. Our results showed that chloroquine and insulin were
independently effective in lowering fasting blood glucose level in alloxan
treated animals. Also chloroquine significantly raises blood serum insulin
level in diabetic animals without exogenous insulin treatment. Chloroquine
restored partially or completely the level of transferrin, antitrypsin, acid
glycoprotein and immunoglobulin G significantly and more efficiently than
insulin. Both chloroquine and insulin had no influence on restoring the level
of albumin in diabetic mice. The results indicate that chloroquine treatment
may be a good adjuvant therapy with insulin to control diabetes and its
complications

DOI

10.21608/eajbsc.2014.16041

Keywords

Chloroquine, Alloxan Diabetes Blood serum proteins Glucose

Authors

First Name

Abdallah

Last Name

Mahmoud

MiddleName

B.

Affiliation

Laboratory of Molecular Cell Biology, Department of Zoology, Faculty of Science, Assiut university, Assiut 71516, Egypt

Email

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City

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Orcid

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First Name

Alshaimaa

Last Name

Alghriany

MiddleName

A.

Affiliation

Laboratory of Molecular Cell Biology, Department of Zoology, Faculty of Science, Assiut university, Assiut 71516, Egypt

Email

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City

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Orcid

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First Name

Abo Bakr

Last Name

Abdel Shakor

MiddleName

M.

Affiliation

Laboratory of Molecular Cell Biology, Department of Zoology, Faculty of Science, Assiut university, Assiut 71516, Egypt

Email

eltayeb702002@yahoo.com

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Orcid

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Volume

6

Article Issue

2

Related Issue

2654

Issue Date

2014-12-01

Receive Date

2018-10-06

Publish Date

2014-12-01

Page Start

138

Page End

148

Print ISSN

2090-0767

Online ISSN

2090-083X

Article File

EAJBSC_Volume 6_Issue 2_Pages 138-148.pdf

PDF . 821.9kB

Link

https://eajbsc.journals.ekb.eg/article_16041.html

Detail API

https://eajbsc.journals.ekb.eg/service?article_code=16041

Order

17

Type

Original Article

Type Code

673

Publication Type

Journal

Publication Title

Egyptian Academic Journal of Biological Sciences. C, Physiology and Molecular Biology

Publication Link

https://eajbsc.journals.ekb.eg/

MainTitle

The effect of chloroquine induced hypoglycemia on the levels of major blood serum proteins in diabetic mice

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Article

Created At

22 Jan 2023