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16033

The Anti-Proliferative Effect of Hesperidin on Hepatocarcinoma Cells HepG2

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Last updated: 22 Jan 2023

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Abstract

This
study investigates the antiproliferative effect of hesperidin on human
hepatocarcinoma HepG2 cell line. Different concentrations of hesperidin 25, 50 et
al. 100 µM were used for different time intervals 24, 48 et al. 72
hrs, while untreated cells were served as control. The effects of different
concentrations of hesperidin on HepG2 cell viability, nuclear factor kappa-B
(NF-kB) gene expression et al. alpha-fetoprotein (AFP) secretion from
the cells were measured. The results of the cell viability assays showed that
hesperidin concentrations exhibited a highly significant inhibition effect on
HepG2 cell proliferation which was evidenced by reduction in viable cells
count. The results were confirmed by microscopical observations of cell
morphology. Furthermore, hesperidin suppressed the activity of NF-kB gene
expression of HepG2 cells compared to the control. Also it caused a highly
significant depression in the level of AFP in HepG2 cells compared with that of
controls in time dependent manner. Therefore, the conclusion was that
hesperidin inhibits the growth of HepG2 cells through suppressing the activity
of NF-kB gene expression et al. modulates the biochemical marker AFP.

DOI

10.21608/eajbsc.2014.16033

Keywords

HepG2 cell line, Hesperidin, NF-kB, Antiproliferative effect

Authors

First Name

Shadia

Last Name

Fathy

MiddleName

A.

Affiliation

Biochemistry department, Faculty of Science, Ain Shams University, Egypt.

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Orcid

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First Name

Fatma

Last Name

Abdel-Hamid

MiddleName

F.

Affiliation

Biochemistry department, Faculty of Science, Ain Shams University, Egypt.

Email

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City

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Orcid

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First Name

Sara

Last Name

Agwa

MiddleName

A.

Affiliation

Clinical & Chemical Pathology department, Faculty of Medicine, Ain Shams University, Egypt

Email

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City

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Orcid

-

First Name

Samah

Last Name

El-Diasty

MiddleName

M.

Affiliation

1- Biochemistry department, Faculty of Science, Ain Shams University, Egypt

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City

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Orcid

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Volume

6

Article Issue

2

Related Issue

2654

Issue Date

2014-12-01

Receive Date

2018-10-06

Publish Date

2014-12-01

Page Start

75

Page End

83

Print ISSN

2090-0767

Online ISSN

2090-083X

Article File

EAJBSC_Volume 6_Issue 2_Pages 75-83.pdf

PDF . 384.9kB

Link

https://eajbsc.journals.ekb.eg/article_16033.html

Detail API

https://eajbsc.journals.ekb.eg/service?article_code=16033

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9

Type

Original Article

Type Code

673

Publication Type

Journal

Publication Title

Egyptian Academic Journal of Biological Sciences. C, Physiology and Molecular Biology

Publication Link

https://eajbsc.journals.ekb.eg/

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Article

Created At

22 Jan 2023