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13696

Biochemical Effects of Bradykinin Potentiating Factor (BPF) Isolated from Scorpion Venom ( Leiurus quinquestriatus) against CCl4- Liver Injury in Male Albino Rats.

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Last updated: 22 Jan 2023

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Abstract

The main purpose of this study is to evaluate the ability of bradykinin potentiating factor (BPF) isolated from scorpion venom (Leiurus quinquestriatus) in treatment of liver injuries which induced by injection of CCl4in male Albino rats. Male Albino rats (250±20 g. body weight) were divided into four groups. In the control group; Albino rats were interaperitoneally (i.p) injected with 100 µL saline solution. The second group (i.p) injected with BPF in 100 µL saline solutions (1μgm/g. b. w. per 5 days).  Third and fourth groups were i.p. injected with 0.5 ml/kg body weight (b. w.) twice weekly of CCl4 for fifteen days, after that only the fourth group was treated by BPF in 100 µL saline solutions (1μgm/g. b. w. per 5 days). The results indicated that, CCl4 injection induced a significant decrease in serum catalase (CAT), superoxide dismutase (SOD), reduced glutathione (GSH), total protein and albumin, within thirty days post-injection of CCl4 as compared to the normal control group. In contrast, CCl4 induced a significant increase in malondialdehyde(MDA), aspartate amino transferase (AST), alanine amino transferase (ALT), and alkaline phosphatase (ALP) compared to normal control animals. The efficiency of BPF treatment is alleviation the effects of CCl4 on these parameters. The improvement of these parameters may be attributed to the release antioxidant and cytokines and/or amelioration of the toxic effects of CCl4 on the liver.

DOI

10.21608/eajbsc.2015.13696

Keywords

Scorpion venom, L. quinquestriatus, BPF, CCl4, liver injury and, albino rats

Authors

First Name

Muhammad

Last Name

Salman

MiddleName

M. A.

Affiliation

Department of Zoology, Faculty of Science, South Valley University, Qena, Egypt

Email

salman2_52014@yahoo.com

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Orcid

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Volume

7

Article Issue

2

Related Issue

2651

Issue Date

2015-12-01

Receive Date

2018-09-15

Publish Date

2015-12-01

Page Start

115

Page End

126

Print ISSN

2090-0767

Online ISSN

2090-083X

Link

https://eajbsc.journals.ekb.eg/article_13696.html

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https://eajbsc.journals.ekb.eg/service?article_code=13696

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12

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Original Article

Type Code

673

Publication Type

Journal

Publication Title

Egyptian Academic Journal of Biological Sciences. C, Physiology and Molecular Biology

Publication Link

https://eajbsc.journals.ekb.eg/

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Article

Created At

22 Jan 2023