Twenty Iraqi breast cancer cases were included in this study to detect the protein expression of vascular endothelial growth factor (VEGF) and endostatin (ES) in the women patients from Saladin governorate breast tissues, among breast cancer cases. Hematoxylin and Eosin (H and E) stained then immunohistochemically (IHC) designed for vascular endothelial growth factor (VEGF) and Endostatin. Regarding to histological grading, the results showed that among 20 patients 17 cases were grade II and 3 cases were grade III, while staging system  8 cases were stages (II); 12 cases were stage III. Immunohistochemical IHC study expression of Vascular endothelial growth factor VEGF in breast cancer groups shows positive expression found in 14 (70%) out of 20 cases of the Saladin breast can cercases with P value  <0.001, Endostatin expression was observed in 15 (75%) out of 20 samples of the Saladin breast cancer patients with P value  <0.05.  Correlation between the two studied markers VEGF and ES was studied statistically and the study revealed that there was a strong significant relationship between the VEGF expression and expression of ES (P value <0.01), and also there was significant relationship between expression of VEGF and ES with grading (P value >0.001) and staging system of breast cancer patients (P value >0.05).