The olive leaf moth Palpita unionalis (Lepidoptera: Pyralidae) is an economic pest of the commercial olive groves in Egypt and different Mediterranean countries. The present study was conducted aiming to assess the disturbing effects of three novel IGRs, viz.  Novaluron, Methoxyfenozide and Pyriproxyfen (LC₅₀ values: 0.97, 0.176 and 0.00009 ppm, respectively) on the main metabolites (proteins, carbohydrates and lipids) in haemolymph and fat bodies of larvae (24 h-, 48 h- and 72 h-post-treatment) as well as in the developed pupae (3-day, 6-day and 9-day old pupae). Both Novaluron and Pyriproxyfen prevalently enhanced the treated larvae to gain increasing protein content in haemolymph, but Methoxyfenozide enhanced only the 48 h-old larvae. In the fat bodies, all IGRs predominantly prohibited the treated larvae to attain normal protein content. All of the tested IGRs profoundly prevented the developed pupae to attain normal protein level, regardless of the age. The carbohydrate content in haemolymph of larvae was dramatically declined, regardless the age. In larval fat bodies, all of the tested IGRs exerted suppressing actions on the carbohydrate content. In the developed pupae, carbohydrate content had been decreased, regardless of the tested IGR or the pupal age. The total lipid content in the haemolymph of treated larvae was elaborately declined, regardless the larval age. In fat bodies, all IGRs induced the larvae to gain more lipids. In the developed pupae, the lipid content was pronouncedly increased by Novaluron and Methoxyfenozide but dramatically reduced by Pyriproxyfen.