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217532

Therapeutic Role of Nanocurcumin Versus Monosodium Glutamate Toxicity

Article

Last updated: 22 Jan 2023

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Abstract

The use of Nanoparticles (NPs) and nanostructured materials (NSMs) consider a new light in the progress of disease-modifying treatments for many pathological disorders. The present study is an attempt to investigate the curative effect of Nanocurcumin against long-term MSG- administration on rat liver. A total of 40 adult male Wistar albino rats were divided into the following groups: Control group (C) of 14 rats given saline; Nanocurcumin (Nano-Cur) control group of 14 rats inoculated orally with Nano-Cur (100mg/Kg b.wt/day)for 8 weeks; Monosodium group received MSG 10 mg/kg /b. w. for eight weeks; the therapeutic group was first given MSG alone for 4 weeks and was secondly administered Nano-Cur for 4 weeks. At the end of 8 weeks, animals were sacrificed by ether inhalation anesthesia where blood and liver tissues were collected to study biochemical parameters.MSG administration exerted significant elevation of cholesterol, TG, HDL, LDL, VLDL and MDA. Also showed an increase in liver enzymes. On the other hand, in the therapeutic group, Nano-Cur showed significant improvement in the previous parameters. 

DOI

10.21608/eajbsz.2022.217532

Keywords

Monosodium glutamate, Nanocurcumin, Liver dysfunction & lipid profile

Authors

First Name

Mona

Last Name

Mohamed

MiddleName

A.E.

Affiliation

Zoology department, Faculty of Women for Arts, Science and Education, Ain Shams University.

Email

m.abed38@yahoo.com

City

-

Orcid

-

First Name

Walaa

Last Name

El-Nahrawy

MiddleName

A.M.

Affiliation

Zoology department, Faculty of Women for Arts, Science and Education, Ain Shams University.

Email

-

City

-

Orcid

-

First Name

Amr

Last Name

Zaher

MiddleName

M. E.,

Affiliation

Cardiac Surgery, The National Heart Institute

Email

-

City

-

Orcid

-

First Name

Amany

Last Name

Amer

MiddleName

S.

Affiliation

Zoology department, Faculty of Women for Arts, Science and Education, Ain Shams University.

Email

-

City

-

Orcid

-

Volume

14

Article Issue

1

Related Issue

29870

Issue Date

2022-01-01

Receive Date

2021-12-28

Publish Date

2022-02-01

Page Start

55

Page End

65

Print ISSN

2090-0759

Online ISSN

2090-0821

Article File

EAJBSZ_Volume 14_Issue 1_Pages 55-65.pdf

PDF . 741.9kB

Link

https://eajbsz.journals.ekb.eg/article_217532.html

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https://eajbsz.journals.ekb.eg/service?article_code=217532

Order

5

Type

Original Article

Type Code

672

Publication Type

Journal

Publication Title

Egyptian Academic Journal of Biological Sciences, B. Zoology

Publication Link

https://eajbsz.journals.ekb.eg/

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Article

Created At

22 Jan 2023