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210042

Possible Ameliorative Role of Ethanolic Ginger Extract (Zingiber officinale) against Testicular Toxicity Induced By Monosodium Glutamate In Albino Rats

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Last updated: 22 Jan 2023

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Abstract

The paper aims to investigate the protective effect of ethanolic ginger extract against Monosodium glutamate (MSG) induced reproductive disorders in male rats. Forty-eight male albino rats were separated into four experimental groups:  normal control, ginger extract, MSG only, and MSG plus ginger extract groups. All experimental regimens were administrated orally for four weeks. Dissection was done after two and four weeks from the starting of the experiment. Body and testis weight, sperm abnormalities, biochemical investigations were recorded. Additionally, molecular, histopathological, and immunohistochemical techniques in testis tissue were performed. The present data shows a significant increase in body weight, sperm abnormalities, and serum total cholesterol, with a significant decline in testis weight, serum Follicle-stimulating hormone (FSH), Luteinizing hormone (LH), and testosterone levels after MSG administration. There was an upregulation in the expression of Bax protein whereas downregulation in the expression of B-cell lymphoma-2 (BCL-2) protein in the MSG group when compared with the normal control. Furthermore, testicular alterations were distinguished in the group treated with MSG only, along with enhanced caspase-3 and declined BCl-2 positive cells in testis tissue. While administration with ethanolic ginger extract showed an ameliorative effect contrasted with testicular alterations produced by Monosodium glutamate. 

DOI

10.21608/eajbsz.2021.210042

Keywords

Monosodium glutamate (MSG), testicular alterations, Food additive, Oxidative Stress, Zingiber officinale

Authors

First Name

Heba

Last Name

Mohamed

MiddleName

A.

Affiliation

Zoology Department. Faculty of Women for Arts, Science and Education, Ain Shams University. Cairo, Egypt

Email

dr.hbh2015@women.asu.edu.eg

City

-

Orcid

-

First Name

Mona

Last Name

Mohamed

MiddleName

A. F.

Affiliation

Zoology Department. Faculty of Women for Arts, Science and Education, Ain Shams University. Cairo, Egypt

Email

dr.mona.ahmed@women.asu.edu.eg

City

-

Orcid

-

First Name

Afaf

Last Name

Kamel.

MiddleName

H.

Affiliation

Zoology Department. Faculty of Women for Arts, Science and Education, Ain Shams University. Cairo, Egypt

Email

afaf.hendawy@women.asu.edu.eg

City

-

Orcid

-

Volume

13

Article Issue

2

Related Issue

26137

Issue Date

2021-12-01

Receive Date

2021-11-09

Publish Date

2021-12-01

Page Start

285

Page End

300

Print ISSN

2090-0759

Online ISSN

2090-0821

Article File

EAJBSZ_Volume 13_Issue 2_Pages 285-300.pdf

PDF . 965.7kB

Link

https://eajbsz.journals.ekb.eg/article_210042.html

Detail API

https://eajbsz.journals.ekb.eg/service?article_code=210042

Order

23

Type

Original Article

Type Code

672

Publication Type

Journal

Publication Title

Egyptian Academic Journal of Biological Sciences, B. Zoology

Publication Link

https://eajbsz.journals.ekb.eg/

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Article

Created At

22 Jan 2023