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208185

The Toxic Effect of Indoxacarb Exposure on Some Hematological and Hormonal Indices and Evaluating the Potential Alleviative Effects of Vitamin C and Zinc in Male Albino Rats

Article

Last updated: 24 Dec 2024

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Abstract

The world is facing very severe disasters, most notably the toxic effects of pesticides on living organisms' health and the environment, whether directly or indirectly and in the short or long term. Some developing countries suffer from severe shortcomings regarding the necessary precautions to reduce the potential toxicity risks from handling or exposure to pesticides. This work achieved to study the toxic effect of sub-lethal dose of indoxacarb (100 mg/kg) exposure and evaluate the protective effects of vitamin C (200 mg/kg) and zinc (Zn) (100 mg/kg) (separately or together) in male albino rats. The experimental rats were randomly divided into five groups (n=6): control group, indoxacarb-treated group < span>, indoxacarb+vitamin C- treated group < span>, indoxacarb+Zn- treated group, and indoxacarb+vitamin C+Zn- treated group. All groups received orally the tested doses every 48 h for 21 days. The results indicated that indoxacarb induced significant changes of some hematological parameters (red blood cells (RBC) counts, white blood cells (WBC) counts, hemoglobin (Hb) content, hematocrit (Hct) value, mean corpuscular volume (MCV) and platelets counts) besides substantial alterations in the thyroid hormones (tri-iodothyronine (T3), thyroxine (T4), and thyroid-stimulating hormone (TSH)) and the sex hormones (total and free testosterone, progesterone, and estradiol). Furthermore, the administration of vitamin C and zinc together alleviated the alteration of later hematological and hormonal parameters in indoxacarb-treated rats.
Conclusion: a mixture of vitamin C and zinc may show ameliorating effects against indoxacarb-toxicity through improving the examined biochemical parameters about the use of both alone.

DOI

10.21608/eajbsz.2021.208185

Keywords

albino rats, hematological parameters, Hormonal parameters, Indoxacarb, vitamin c, zinc

Authors

First Name

Hanaa

Last Name

Hassan

MiddleName

F.

Affiliation

Zoology Department, Faculty of Science, Minia University 61519, Minia, Egypt

Email

hanaafawzy78@mu.edu.eg

City

-

Orcid

-

First Name

Noha

Last Name

Meligi

MiddleName

M.

Affiliation

Zoology Department, Faculty of Science, Minia University 61519, Minia, Egypt

Email

noha.melege@mu.edu.eg

City

-

Orcid

-

Volume

13

Article Issue

2

Related Issue

26137

Issue Date

2021-12-01

Receive Date

2021-11-06

Publish Date

2021-12-01

Page Start

259

Page End

270

Print ISSN

2090-0759

Online ISSN

2090-0821

Article File

EAJBSZ_Volume 13_Issue 2_Pages 259-270.pdf

PDF . 751.7kB

Link

https://eajbsz.journals.ekb.eg/article_208185.html

Detail API

https://eajbsz.journals.ekb.eg/service?article_code=208185

Order

21

Type

Original Article

Type Code

672

Publication Type

Journal

Publication Title

Egyptian Academic Journal of Biological Sciences, B. Zoology

Publication Link

https://eajbsz.journals.ekb.eg/

MainTitle

The Toxic Effect of Indoxacarb Exposure on Some Hematological and Hormonal Indices and Evaluating the Potential Alleviative Effects of Vitamin C and Zinc in Male Albino Rats

Details

Type

Article

Created At

22 Jan 2023