The present study was designed to determine the possible therapeutic effects of royal jelly against carbon tetrachloride (CCl₄) induced oxidative stress and biochemical changes in the kidney of albino rats. A patch of 20 male albino rats averaged weights (190±10 g) at the beginning of the experiment were divided into 4 main groups according to the treatment and requirements of the experiment. The rats injected i.p. with CCl₄ at a dose (1 mL/kg, 1:1 in olive oil) twice per week and received, via gavage, royal jelly at a dose (400 mg/kg b. wt) along the experimental period. Each group contains 5 rats that were sacrificed on the45 days from the start of the experiment. The results refer to a significant elevation of renal parameters (creatinine, blood Urea and Uric acid) on the 6^th week in rats injected intraperitoneal with CCl₄ as compared to the control groups. The administration of the royal jelly has beneficial and decrease side effects against the deleterious changes of CCl₄.
      In conclusion, according to the results obtained the administration of the royal jelly provides considerable nephroprotective effects against intoxicated with CCl₄ in male Wister albino rats by preventing oxidative stress through ROS scavenger and improvement in the former biochemical parameters.