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113163

Chromosomal Aberrations Due to Acrylamide Exposure and The Protective Role of L-arginine in Bone Marrow Cells of Male Albino Rats.

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Last updated: 03 Jan 2025

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Abstract

Acrylamide (Acr) is a human carcinogen which generated in foodstuffs rich with carbohydrates during overheating. It has been recorded to induce carcinogenic and genotoxic effects in experimental animals. So, the present work aimed to evaluate the genotoxic effect of Acr and the possible protective role of L-arginine (amino acid) against Acr genotoxicity using the chromosomal aberration assay in male albino rats (Rattus norvegicus). In the current investigation, 20 male albino rats were equally divided into four main groups (n = 5); Group1 (control): Animals were received the ordinary water and diet. Group2 (L- arginine): Animals were given L- arginine at a dose of 200mg/kg/day for a month by oral gavage. Group3 (acrylamide): Animals were given Acr at a dose of 50mg/kg/day for a month by oral gavage. Group4 (Acrylymide+ L-arginine): Animals were given Arc (50mg/kg/day) together with L-arginine (200mg/kg/day) for a month by oral gavage. The results of the present work concluded that Acr is a genotoxic agent, it induced a significant increase in the frequency of total chromosomal aberrations (numerical and structural). L-arginine provides a protective potential against genotoxicity induced by Acr and this was supported by a significant reduction in the frequency of chromosomal aberrations although, the value remained higher and significant as compared with control group. 

DOI

10.21608/eajbsz.2020.113163

Keywords

acrylamide, L-arginine, chromosomal aberrations, albino rats

Authors

First Name

Sabha

Last Name

Elballat

MiddleName

E.

Affiliation

Zoology Department, Faculty of Science, Zagazig University, Egypt

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Orcid

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First Name

Ghada

Last Name

El Fakahani

MiddleName

A.

Affiliation

Zoology Department, Faculty of Science, Zagazig University, Egypt

Email

alighada621@gmail.com

City

-

Orcid

-

First Name

Samir

Last Name

Nassar

MiddleName

A.

Affiliation

Zoology Department, Faculty of Science, Zagazig University, Egypt

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Orcid

-

Volume

12

Article Issue

2

Related Issue

15675

Issue Date

2020-12-01

Receive Date

2020-07-08

Publish Date

2020-12-01

Page Start

83

Page End

92

Print ISSN

2090-0759

Online ISSN

2090-0821

Link

https://eajbsz.journals.ekb.eg/article_113163.html

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https://eajbsz.journals.ekb.eg/service?article_code=113163

Order

8

Type

Original Article

Type Code

672

Publication Type

Journal

Publication Title

Egyptian Academic Journal of Biological Sciences, B. Zoology

Publication Link

https://eajbsz.journals.ekb.eg/

MainTitle

Chromosomal Aberrations Due to Acrylamide Exposure and The Protective Role of L-arginine in Bone Marrow Cells of Male Albino Rats.

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Article

Created At

22 Jan 2023