Field experiments were carried on soybean variety (Giza 111) during two successive seasons 2019 and 2020. Two natural compounds were tested, Humic acid, Chitosan Nano-particles (C.N.Ps) and a common acaricide, Abamectin, of recommended dose rates and one treatment left without spraying as control by using Economy Micron ULVA sprayer (15L./fed.) and Hydraulic sprayer (Matabi) (56 L/Fed.). Data indicated that all tested compounds induced significant negative influenced on Tetranychus urticae adult females' survival. Abamectin and humic acid revealed successful results followed by the C.N.Ps. Results showed that C.N.Ps have lower toxicity on T. urticae but it safer on all movable stages of  Amblyseius californicus, Orius insidiosus, and Scolothrips sexmaculatus, the natural enemies associated.  It could be recommended that using those compounds with LV spraying equipment with not less than (15 L. /Fed.). A satisfactory spray coverage was obtained on soybean plants. The droplets spectrum ranging from 150-170 mm (VMD). A sufficient number ranging from 18-199 N/cm². The data showed that the Economy Micron ULVA sprayer was the best equipment to control. Tetranychus urticae on soybean according to the homogeneity of the droplet spectrum. The rate of performance of Hand-held Hydraulic sprayer (Matabi) (56 L. /Fed.), Economy Micron ULVA (15 L. /Fed.) were 3.55 Fed. /day, 3.30 Fed. /day, respectively. Data also revealed that lost spray-on ground for Ulva sprayer was lower than Matabi sprayer with 35%.