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30839

Toxic and Teratogenic Effects of Sampa-Sampalukan (Phyllanthus niruri) Leaves Extract Using Danio rerio Embryo Assay

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Last updated: 22 Jan 2023

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Abstract

  This paper established toxic and teratogenic effects of P. nururi leaves extract to the embryonic development of D. rerio. After 12 hours of exposure to various treatment concentrations, 100% coagulated embryos were observed in 1% and higher concentrations. Meanwhile, mortality in lower concentrations was found to be as time and dose-dependent. Coagulation was the most remarkable toxic effect of the plant leaves extract. On the other hand, heartbeat and hatchability rate of zebrafish embryo was affected in a dose-dependent manner. In teratogenicity testing, tail malformation was the most evident teratogenic effect of the plant leaves extract. Taken together, P. niruri leaves extract was embryo-toxic and teratogenic to D. rerio. 

DOI

10.21608/eajbsz.2019.30839

Keywords

Danio rerio, embryo-toxicity, Phyllanthus niruri, Sampa-sampalukan, teratogenicity, zebrafish

Authors

First Name

I.

Last Name

Lamban

MiddleName

Q.

Affiliation

Assemblywoman Felicita G. Bernardino Memorial Trade School, Lias Marilao, Bulacan, Philippines

Email

-

City

-

Orcid

-

First Name

E.

Last Name

Balbeuna

MiddleName

S.

Affiliation

Assemblywoman Felicita G. Bernardino Memorial Trade School, Lias Marilao, Bulacan, Philippines

Email

-

City

-

Orcid

-

First Name

M.

Last Name

Lee

MiddleName

Y. S.

Affiliation

Department of Biology, College of Science, Bulacan State University, City of Malolos, Bulacan, Philippines

Email

-

City

-

Orcid

-

First Name

M.

Last Name

Sacdalan

MiddleName

-

Affiliation

Department of Biology, College of Science, Bulacan State University, City of Malolos, Bulacan, Philippines

Email

-

City

-

Orcid

-

First Name

A.

Last Name

arpio JR.

MiddleName

P.

Affiliation

Department of Biology, College of Science, Bulacan State University, City of Malolos, Bulacan, Philippines

Email

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City

-

Orcid

-

First Name

Kevin Smith

Last Name

Cabuhat

MiddleName

P.

Affiliation

AD-DRUGSTEL Pharmaceutical Laboratories Incorporation, First Bulacan Industrial City, Tikay, Malolos, Bulacan, Philippines

Email

kevinsmithcabuhat@yahoo.com

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-

Orcid

-

Volume

11

Article Issue

1

Related Issue

4884

Issue Date

2019-06-01

Receive Date

2019-01-12

Publish Date

2019-06-01

Page Start

109

Page End

115

Print ISSN

2090-0759

Online ISSN

2090-0821

Article File

EAJBSZ_Volume 11_Issue 1_Pages 109-115.pdf

PDF . 950.2kB

Link

https://eajbsz.journals.ekb.eg/article_30839.html

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https://eajbsz.journals.ekb.eg/service?article_code=30839

Order

11

Type

Original Article

Type Code

672

Publication Type

Journal

Publication Title

Egyptian Academic Journal of Biological Sciences, B. Zoology

Publication Link

https://eajbsz.journals.ekb.eg/

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Article

Created At

22 Jan 2023