Background: Electromagnetic fields has increased gradually due to technology expansion and thus continues exposure to it may affect the biological system, so that the present work aimed to study the biological effect of non-ionizing radiation magnetic field from power line of 50 Hz which caused by devices become widely used in human activity on the structural properties of cerebral cortex and the possible protective role of vitamin E on it  through the histopathological and immunohistochemical  study  .
Result: Thirty mice were divided into three groups, group I  (control) , group II animals of this group exposed to extremely low frequency magnetic field (ELF – MF) generated  by electrical device (2mT- 20G)  for a total  period 45 day(2h/day)  and  group III exposed to the same field and period after adding vitamin E (200 mg /kg) B.W. along with  the drinking water. The results showed many changes such as neuronal degeneration and apoptosis in number of Purkinje cells and showing a decreased reactivity in carbohydrates , protein ,DNA and Glial Fibrillary Acidic Protein (GFAP)  content in (MF) treated group as compared to control , such  changes showed improvement of the histolomorpholigical and immunohistochemical changes in magnetic field (MF) and vitamin E treated group. 
Conclusion: Electromagnetic fields exposure led to degenerative changes on cerebellar cortex, and the data collected from histopathological and immunohistochemical  study  revealed  a protective effect of vitamin E on  cellular cortex layers of the cerebellar cortex