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22733

Assessment of the Toxic and Teratogenic Effects of Kamagong (Diospyros discolor Willd.) Leaves Extract to the Developing Embryo of Zebrafish (Danio rerio)

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Last updated: 03 Jan 2025

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Abstract

This work highlighted the embryo-toxic and teratogenic effects of D. discolor leaves extract to the embryo of D. rerio, a model. Apparently, 100% mortality of embryos was observed in 5% and 10% treatment concentration at 12 hpta. Meanwhile, mortality in lower concentrations increases as time of exposure is prolonged and as the amount of treatment concentration increases. Coagulation was the toxic effect of the plant water extract. On the other hand, heartbeat and hatchability rate decreases as the amount of treatment concentration increases. In terms of teratogenicity, tail malformation was the most marked teratogenic effect of the plant extract. Moreover, growth retardation, head malformation, yolk deformities and abdominal edema were observed. Altogether, D. discolor leaves water extract exhibit toxic and teratogenic effects against D. rerio embryo. Thus, this plant contains active phytochemical components that can be developed as anticancer drugs.

DOI

10.21608/eajbsz.2018.22733

Authors

First Name

J.

Last Name

Flaviano

MiddleName

F.

Affiliation

Assemblywoman Felicita G. Bernardino Memorial Trade School, Lias Marilao, Bilacan, Philippines

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-

Orcid

-

First Name

M.

Last Name

Kenniker

MiddleName

A. A.

Affiliation

Assemblywoman Felicita G. Bernardino Memorial Trade School, Lias Marilao, Bilacan, Philippines

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-

City

-

Orcid

-

First Name

F.

Last Name

Ganda

MiddleName

J. C.

Affiliation

Assemblywoman Felicita G. Bernardino Memorial Trade School, Lias Marilao, Bilacan, Philippines

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-

Orcid

-

First Name

J.

Last Name

Sacedor

MiddleName

-

Affiliation

Assemblywoman Felicita G. Bernardino Memorial Trade School, Lias Marilao, Bilacan, Philippines

Email

-

City

-

Orcid

-

First Name

M.

Last Name

Lee

MiddleName

Y. S.

Affiliation

Department of Biology, College of Science, Bulacan State University, City of Malolos, Bulacan, Philippines

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-

City

-

Orcid

-

First Name

K.

Last Name

Cabuhat

MiddleName

S. P.

Affiliation

AD-Drugstel Pharmaceutical Laboratories Inc., First Bulacan Industrial City, Tikay Malolos, Bulacan, Philippines

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Volume

10

Article Issue

2

Related Issue

4310

Issue Date

2018-12-01

Receive Date

2018-12-24

Publish Date

2018-12-01

Page Start

53

Page End

60

Print ISSN

2090-0759

Online ISSN

2090-0821

Article File

EAJBSZ_Volume 10_Issue 2_Pages 53-60.pdf

PDF . 566.8kB

Link

https://eajbsz.journals.ekb.eg/article_22733.html

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https://eajbsz.journals.ekb.eg/service?article_code=22733

Order

5

Type

Original Article

Type Code

672

Publication Type

Journal

Publication Title

Egyptian Academic Journal of Biological Sciences, B. Zoology

Publication Link

https://eajbsz.journals.ekb.eg/

MainTitle

Assessment of the Toxic and Teratogenic Effects of Kamagong (Diospyros discolor Willd.) Leaves Extract to the Developing Embryo of Zebrafish (Danio rerio)

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Article

Created At

22 Jan 2023