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22732

Effects of Fullerene C60 and Fruit Extract of Balanites aegyptiaca Plant on the Nephrotoxicity and Hematotoxicity Induced by Doxorubicin in Diabetic Male Albino Rats.

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Last updated: 22 Jan 2023

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Abstract

There was a relationship between hyperglycemia and pharmakinetic of toxicity of doxorubicin that leads to increasing oxidative stress on cells. This study was aimed to detect the curative effect of some antioxidants drugs (fullerene C60 and mesocarp fruit extract of  Balanites aegyptaica) on the hematological  and biochemical of kidney function  parameters after induced by diabetes and toxicity with doxorubicin on the rats. nine groups of adult male albino rats were established (n= 8). The first group (Gp. 1) was served as a normal group. Gp. 2 was injected intraperitoneal (i.p.) with by streptozotocin at a single dose (45 mg/kg body weight). Diabetic rats (Gp. 3)were injected intraperitoneal (i.p.) with doxorubicin at the dose (5mg/kg body weight)for three  days.Diabetic  rats (Gp. 4) was given orally fullerene C60 daily at the dose (4 mg/kg body weight).Diabetic rats (Gp. 5) treated orally bymesocarp fruit extract of  Balanites aegyptaicaat dose (1.5ml/kg. body weight). Diabetic rats(Gp. 6) treated orally with fullerene C60 plus mesocarp fruit extract of  Balanites aegyptaica. Diabetic rats (Gp. 7) intoxicated DOX treated orally with fullerene C60. Diabetic rats (Gp. 8) intoxicated DOX treated orally with mesocarp fruit extract of  Balanites aegyptaica. Diabetic rats (Gp. 9) treated orally with fullerene C60 plus mesocarp fruit extract of  Balanites aegyptaica. Whole blood and serum were collected for hematological and biochemical of kidney functions examinations, respectively. Diabetes induces, hematotoxicity was determined by a highly significant decrease in red blood cells (RBCs), white blood cells (WBCs), blood Platelets (PLTs), haemoglobin (Hb) and PCV value, as well as nephropathy was determined by a highly significant increase in creatinne, urea and uric acid. diabetic rats intoxicated DOX showed the reduction in hematological parameters, also, there were a highly significant increase in kidney function parameters. Fullerene C60 and  mesocarp fruit extract of  Balanites aegyptaica meliorated  hematological and kidney functions indices.  It could be concluded that Fullerene C60 and Balanites aegyptiaca, clarified a modulatory role against the cellular damage produced by oxidative stress.

DOI

10.21608/eajbsz.2018.22732

Keywords

diabetic rats, Doxorubicin, Fullerene and Balanites aegyptaica

Authors

First Name

Abd EL-Raheim

Last Name

EL-Shater

MiddleName

A.

Affiliation

Zoology Department, Faculty of Science; South Valley University, Qena

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Orcid

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First Name

Muhammad

Last Name

Salman

MiddleName

M. M. A.

Affiliation

Zoology Department, Faculty of Science; South Valley University, Qena

Email

salman2_2014@yahoo.com

City

-

Orcid

-

First Name

Naglaa

Last Name

Kasem

MiddleName

R. A.

Affiliation

Zoology Department, Faculty of Science; South Valley University, Qena

Email

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City

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Orcid

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First Name

Mariam

Last Name

Fawy

MiddleName

A.

Affiliation

Zoology Department, Faculty of Science; South Valley University, Qena

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City

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Orcid

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Volume

10

Article Issue

2

Related Issue

4310

Issue Date

2018-12-01

Receive Date

2018-12-24

Publish Date

2018-12-01

Page Start

41

Page End

52

Print ISSN

2090-0759

Online ISSN

2090-0821

Link

https://eajbsz.journals.ekb.eg/article_22732.html

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https://eajbsz.journals.ekb.eg/service?article_code=22732

Order

4

Type

Original Article

Type Code

672

Publication Type

Journal

Publication Title

Egyptian Academic Journal of Biological Sciences, B. Zoology

Publication Link

https://eajbsz.journals.ekb.eg/

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Article

Created At

22 Jan 2023