There was a relationship between hyperglycemia and pharmakinetic of toxicity of doxorubicin that leads to increasing oxidative stress on cells. This study was aimed to detect the curative effect of some antioxidants drugs (fullerene C₆₀ and mesocarp fruit extract of  Balanites aegyptaica) on the hematological  and biochemical of kidney function  parameters after induced by diabetes and toxicity with doxorubicin on the rats. nine groups of adult male albino rats were established (n= 8). The first group (Gp. 1) was served as a normal group. Gp. 2 was injected intraperitoneal (i.p.) with by streptozotocin at a single dose (45 mg/kg body weight). Diabetic rats (Gp. 3)were injected intraperitoneal (i.p.) with doxorubicin at the dose (5mg/kg body weight)for three  days.Diabetic  rats (Gp. 4) was given orally fullerene C₆₀ daily at the dose (4 mg/kg body weight).Diabetic rats (Gp. 5) treated orally bymesocarp fruit extract of  Balanites aegyptaicaat dose (1.5ml/kg. body weight). Diabetic rats(Gp. 6) treated orally with fullerene C₆₀ plus mesocarp fruit extract of  Balanites aegyptaica. Diabetic rats (Gp. 7) intoxicated DOX treated orally with fullerene C₆₀. Diabetic rats (Gp. 8) intoxicated DOX treated orally with mesocarp fruit extract of  Balanites aegyptaica. Diabetic rats (Gp. 9) treated orally with fullerene C₆₀ plus mesocarp fruit extract of  Balanites aegyptaica. Whole blood and serum were collected for hematological and biochemical of kidney functions examinations, respectively. Diabetes induces, hematotoxicity was determined by a highly significant decrease in red blood cells (RBCs), white blood cells (WBCs), blood Platelets (PLTs), haemoglobin (Hb) and PCV value, as well as nephropathy was determined by a highly significant increase in creatinne, urea and uric acid. diabetic rats intoxicated DOX showed the reduction in hematological parameters, also, there were a highly significant increase in kidney function parameters. Fullerene C₆₀ and  mesocarp fruit extract of  Balanites aegyptaica meliorated  hematological and kidney functions indices.  It could be concluded that Fullerene C₆₀ and Balanites aegyptiaca, clarified a modulatory role against the cellular damage produced by oxidative stress.