Monthly and seasonal fluctuations in densities of freshwater snails were recorded in six different sites at Qena Governorate during the period of March 2009 February 2010. The study revealed the occurrence of 13 species of freshwater snails belonging to 9 families of class Gastropoda. The snail species and their total catch were: Cleopatra bulimoides (1704 specimens), Lanistes carinatus (1468 specimens), Melanoides tuberculata (1036 specimens), Gabbiella senaariensis (731 specimens) Theodoxus niloticus (670 specimens), Bellamya unicolor (588 specimens), Physa acuta (213 specimens), Lymnaea natalensis (145 specimens), Succinea cleopatra (85 specimens), Bulinus truncatus (73 specimens), Biomphalaria alexandrina (41 specimens), Gyraulus ehrenbergi (12 specimens) and Helisoma duryi (2 specimens) in a descending order. The densities of the recorded snails varied seasonally and the general seasonal peak was recorded during Autumn while the lowest density observed during Winter. Ecological factors which may influence the distribution of the recorded snails were also determined (water temperature, pH, dissolved oxygen conductivity, total hardness, total dissolved salts, water depth and percentage of macrophytes).