Bisphenol-A (BPA) or 2,2-bis (4-hydroxyphenyl) propane is a compound widely used in the production of polycarbonate and other plastic industries. In this study, 45 fishes (Cirrhinus mrigala) weighing 90 ± 5 g were used and divided into 3 groups of fifteen each. 1^st Group received fish diet only and served as control, 2^nd group were exposed with Bisphenol-A (2mg/l) and 3^rd group were exposed with vitamin-C (50 mg/l) along with Bisphenol-A (2mg/l), respectively for 15, 30 and 60 days and the protein contents were estimated in brain and testis. The significantly increased in protein levels were noticed in brain and testis after 15, 30 and 60 days of Bisphenol-A exposed as compared to control group. While, the animals supplemented with vitamin-C along with Bisphenol-A were showed insignificantly decreased in protein level in brain and testis after 15 and 30 days as compared to Bisphenol-A group. However, this levels were significantly lowered in brain and testis after 60 days as compared to Bisphenol-A. These results indicate that vitamin-C work as an antidote against Bisphenol-A toxicity in freshwater fish Cirrhinus mrigala.