Effect of different compounds against some principle calcium precipitation parameters in shell was studied on two terrestrial snails, Eobania vermiculata and Monacha obstructa. The tested compounds were Newmyl (the recommended compound), Lambada, Actra as synthetic compound, Tracer (bioinsecticide) and Tannic acid (natural product). Animals of each species were treated with LC₅₀ of each compound using contact technique. The calcium precipitation parameters (Alkaline phosphatase (ALP), Acid phosphatase (ACP), Total protein (TP), Total lipid (TL) and cholesterol) were measured after one, three and seven days post treatment. Results showed that all tested compounds caused vacillated effects for the two snail species. Tannic acid and tracer were the most effective compounds on the all parameters in both species. While the recommended compound (newmyl) came in the last rank in the most of parameters. E. vermiculata was more susceptible to tannic acid than M. obstructa for ALP, ACP enzymes, total protein and cholesterol, while both species had the same response to total lipid. The fluctuation effects of tested biochemical parameters may be due to damage of cells under the impact of treatment with compounds.