The Fusarium species mycotoxin metabolite Zearalenone (ZEA) mimics the animal body production of estrogen and interferes with conception, ovulation, reproductive organ development and fetal development in farm animals as well as in humans. This research paper gives an overview about acute and chronic toxicity of ZEA and ameliorative role of saffron on interior and exterior morphology of female mice (Mus musculus). The morphological changes were seen, when six animals of each experimental group were administrated with ZEA intraperitonially (IP) (2.5mg/kg. b.w) in dimethyl sulphoxide (DMSO) and oral administration of saffron (50mg/kg. b.w)  for 30, 60 and 90 days. Post of each experiment, we observed that estrogenic mycotoxin reduces body weight and increases reproductive organ weight (P-value < 0.01) followed by swelled ovaries, uterus, enlarged teats, and prolapsed vagina. However, animals treated with ZEA+saffron exhibits almost normal morphology of mice. Besides this, mice treated with saffron alone, reveals normal architecture of teats, vagina and reproductive organs. Conclusion: The experimental investigation indicates that ZEA produces various morphological changes, while promising approach of using saffron to protect and enhancing the function of reproductive system and its associated organs has been proved benificial.