The aim of this study was to investigate the effect of replacing alfalfa hay with graded levels of fennel and basil straws in the diets of growing rabbits aged from 5 to 11 weeks. Eighty-four unsexed, weaned New Zealand white rabbits, aged 5 weeks, were randomly assigned to seven dietary treatments (12 rabbits/treatment): A control diet; three diets the basil hay substituted for 25%, 50% and 75% of alfalfa straw; and three diets the fennel hay replaced 25%, 50% and 75% of alfalfa straw. Results obtained showed that replacement of alfalfa hay with 25 % fennel straw significantly reduced average daily gain compared with the other experimental treatments, while no significant difference was observed among the other experimental treatments during the stage 5-8 week. On the contrary, the animals fed diets contained 25 % fennel straw gave significantly higher average body weight gain compared with the other experimental groups and no significant differences were observed among the other experimental treatments during 8-11 weeks. Regarding body weight gain during the total period from 5 to 11 weeks of age, the result indicates that no significant differences among all treatments were detected. The values of FCR showed no significant differences within all tested groups. Rabbits group fed B50% recorded the highest significant digestibility coefficients of dry matter, organic matter, crude protein, ether extract, neutral detergent fiber, acid detergent fiber, TDN and DCP when compared to all groups. Levels of basil straw and fennel straw in rabbit diets induced an insignificant effect on hemicellulose. There were higher dressing and hot carcass percentages were recorded with rabbits fed B50%. Plasma values of total protein, albumin, globulin, cholesterol or Alanine aminotransferase (ALT) and Aspartate aminotransferase (AST) concentration were not significantly affected due to adding basil straw and fennel straw to rabbit diets. Replacement alfalfa hay with fennel and basil straw resulted in decrease feed cost. Rabbits fed B25% showed higher economic efficiency percentage compared to the other treatments. The results revealed that using basil straw and fennel straw at 25% in growing NZW rabbit diets had no detrimental effects on productive performance, the physiological and biochemical status and it could be used economically instead of alfalfa hay.