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43063

EVALUATION OF PHYTOCHEMICAL COMPOUNDS IN Moringa oliefera Lam. EXTRACTS ON CYTOTOXICITY OF MCF-7 CELL LINE

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Last updated: 03 Jan 2025

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Abstract

Moringa olifera Lam. which called "Miracle tree" was an enormous usage of medical, nutritional and economic benefits so its leaves and roots extracts were vitro examined for phytochemicals contents, antioxidant, and cytotoxicity against MCF-7 cell line. Leaves and roots both extracts were estimate using 2,2-di phenyl-1-picryl hydrazyl (DPPH) radical scavenging assay and high performance liquid chromatography (HPLC) to determine phenolic and flavonoids compounds. The leaves  aqueous and ethyl acetate extracts  contained a significantly (p<0.05) more phenolic compounds than root extracts, while roots ethyl acetate extracts were significantly more active  in DPPH assay comparing with aqueous extracts . However, the leaves aqueous extract and roots ethyl extracts were contained high values flavonoids compound but in case of phenolic compounds the aqueous roots ex tract recorded the greatest highest number followed by the leaves ethyl acetate extract. The ethyl acetate extractions for leaves and roots have a high inhibition percentage against breast adenocarcinoma MCF-7 cell line comparing with aqueous extracts.

DOI

10.21608/ajs.2019.43063

Keywords

antioxidant, MCF-7 cell line, HPLC, Moringa olifera leaves and roots, ethyl acetate extract

Authors

First Name

Marwa

Last Name

Abd El Alem

MiddleName

S.

Affiliation

Medicinal and Aromatic Plants Dept., Horticulture Research Institute, Agriculture Research Center, Giza, Egypt

Email

marwa.saad54@yahoo.com

City

-

Orcid

-

First Name

S.

Last Name

Ali

MiddleName

H.

Affiliation

Agric. Biochemistry Dept., Fac. of Agric., Ain Shams Univ., P.O. Box 68 Hadyek Shoubra 11241, Cairo, Egypt

Email

-

City

-

Orcid

-

First Name

M.

Last Name

Sarwat

MiddleName

I.

Affiliation

Agric. Biochemistry Dept., Fac. of Agric., Ain Shams Univ., P.O. Box 68 Hadyek Shoubra 11241, Cairo, Egypt

Email

-

City

-

Orcid

-

First Name

S.

Last Name

Hussein

MiddleName

H.

Affiliation

Medicinal and Aromatic Plants Dept., Horticulture Research Institute, Agriculture Research Center, Giza, Egypt

Email

-

City

-

Orcid

-

Volume

27

Article Issue

1

Related Issue

6761

Issue Date

2019-03-01

Receive Date

2019-02-18

Publish Date

2019-03-01

Page Start

17

Page End

26

Print ISSN

1110-2675

Online ISSN

2636-3585

Link

https://ajs.journals.ekb.eg/article_43063.html

Detail API

https://ajs.journals.ekb.eg/service?article_code=43063

Order

2

Type

Original Article

Type Code

668

Publication Type

Journal

Publication Title

Arab Universities Journal of Agricultural Sciences

Publication Link

https://ajs.journals.ekb.eg/

MainTitle

EVALUATION OF PHYTOCHEMICAL COMPOUNDS IN Moringa oliefera Lam. EXTRACTS ON CYTOTOXICITY OF MCF-7 CELL LINE

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Type

Article

Created At

22 Jan 2023