The current study was performed to investigate effect of three water regimes as well as, three different soil conditioners on the yield and fruit quality of tomato. The studied water regimes were namely; 60, 80 and 100% of class A pan. However; the tested soil conditioners were “soil hanz", “Olygo plus" and “Bioconditioner". Impact of the two investigated factors was studied separately, as well as, the interaction.  The experiment was carried out at El-Dolify Farm, Khatatba, Monofia Governorate during seasons of 2012/2013 and 2013/2014. Tomato hybrid Yara F1 was used in this investigation. The obtained results confirmed that, using the “Soil hanz" due to the significant increments in all tested parameters related to the yield and the fruit quality. Moreover; interaction between “Soil hanz" and any of the three tested water regimes was significantly the best in number of fruits per plant, average fruit weight, early, marketable and total yield.  In addition; it was concluded from the results that; chemical properties of the tomato fruits were improved by applying the “Soil hanz". Concerning the water use efficiency, it was found that, all of the tested soil conditioners resulted a significant effect related to water use efficiency compared to un-treated treatment (control).  Whereas, irrigated the tomato plants under this experimental condition confirmed the validation of using the 80% irrigation regime for irrigation without significant losses in the crop yield.