Bactrocera zonata (Saunders)a pest of great economic importance in South America, needs urgently to be controlled by environmentally friendly methods, as the sterile insect technique for which mass rearing of insects is required. The present study aimed to evaluate the biological and biochemical effect of wheat germ as a new alternative for the yeast used in the mass rearing of B. Zonata to reduce the high yeast cost. The action of incorporation wheat germ in the tested modified diets with three different weights against the standard diet on some biological and biochemical aspects of adults emerged from tested diets was evaluated. The nutritive value of identical modified wheat germ artificial diet and of standard artificial larval diet was analyzed. Using wheat germ in an artificial larval rearing diet played a great role in inducing some biological and biochemical characters as the wheat germ is therefore a unique source of concentrated nutrients, highly valued as a food supplement.