The first part of the work aimed to study the survey of apple trees borers that attack apple orchards in two different geographical regions, at Abo-Mashour and Al-Khatatba locations (Menoufia governorate). Five species were recorded in the study showed, these borers were Synantheden myopaeformis Borkh., Zeuzera pyrina L., Hypothenemus eruditus Westwood., Scolytus amygdali Guer. and Chlorophorus varius Mull (non recorded at Al-Khatatba) . Highest percentages of infestation (26.08 & 21.33 %) were recorded for Sy. myopaeformis followed by Z. pyrina (17.83 &13.01%) at Abo-Mashour and Al-Khatatba, respectively. An annual increase of infested trees with these borers, especially Sy. myopaeformis (10.59 & 9.59) and Z. pyrina (9.22 & 6.62 )give serious indicators to quick devastation and the death of infested trees. The weather factors detected a significant correlation with infestation by different borers except Ch. varius. Also significant differences for both Z. pyrina and S. amygdale were detected in the two regions under study, while the infestation showed insignificant differences of both Sy. myopaeformis and H. eruditus The second part of the study aimed to investigate the role of phytochemical components within apple trees and their relation to the infestation with apple clearwing moth Sy myopaeformis. The analysis by GC-MS chromatograph showed differences in both Chemical composition and the percentages of compounds in the tested wood samples from apple trees under study. In the uninfested young trees (resistant trees), the levels of 9-Octadecenoic acid (Oleic acid), 9-Hexadecanoic acid and Ethyl iso-allocholate were found at higher rates than the uninfested old trees, as they were 31.42%, 14.83% and 5.37% respectively. The infested old trees showed high levels of these chemical compounds compared to uninfested ones as the percentages of 9-Octadecenoic acid (Oleic acid), 9-Hexadecanoic acid and Ethyl iso-allocholate increased by 5.8 fold, 3.1 fold and 3.1 fold, respectively, while the percentages in uninfested old trees were 7.42%, 5.39% and 3.34% respectively.