Thiodicarb is a carbamate insecticide has been used for several years in agriculture. The objective of this study was to investigate the possible protection of vitamin C (10 mg/kg body weight) as antidote against the toxic effect of 1/10 LD50 dose of thiodicarb insecticide in adult male albino rats.                          Animals were treated orally at two periods (10 and 40 days). The percentage of body weights and some biochemical parameters were investigated. The data obtained revealed highly significant decrements in percentage of body weight gain in groups treated with thiodicarb alone or together with vitamin C. A highly significant elevation in serum AST, ALT, ALP, urea, creatinine and glucose in rats treated with thiodicarb only, while certain amelioration for these elevations were detected in the treated groups with vitamin C and thiodicarb. Lipids profile showed an increase in total lipids only in rats treated with thiodicarb for 10 days, while serum total cholesterol was decreased in the same dosing group for 40 days.